You Searched For: ENZO LIFE SCIENCES

Supplier: ENZO LIFE SCIENCES

Description: Naturally occurring mycotoxin produced by many species of <i>Aspergillus</i>. It is metabolised by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.

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Catalog Number: (ENZOALX610022M050)

Supplier: ENZO LIFE SCIENCES

Description: Peroxynitrite indicator.

UOM: 1 * 50 mg

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Catalog Number: (ENZOALX630111M001)

Supplier: ENZO LIFE SCIENCES

Description: Mycotoxin.

UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES

Description: Potent hepatotoxic and hepatocarcinogenic mycotoxin.

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Catalog Number: (ENZOALX620053M005)

Supplier: ENZO LIFE SCIENCES

Description: Fluorescent probe to test Pgp activity

UOM: 1 * 5 mg

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Catalog Number: (ENZOALX610030M025)

Supplier: ENZO LIFE SCIENCES

Description: Amine dye

UOM: 1 * 25 mg

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Catalog Number: (ENZOBMLEI2880001)

Supplier: ENZO LIFE SCIENCES

Description: Active enantiomer of ketoprofen. Inhibits cyclooxygenase.

UOM: 1 * 1 g

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Catalog Number: (ENZOBMLEI3270025)

Supplier: ENZO LIFE SCIENCES

Description: URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

UOM: 1 * 25 mg

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Catalog Number: (ENZOBMLEI3230001)

Supplier: ENZO LIFE SCIENCES

Description: Cathepsin inhibitor

UOM: 1 * 1 mg

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Catalog Number: (ENZOALX804151BC100)

Supplier: ENZO LIFE SCIENCES

Description: BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804177C050)

Supplier: ENZO LIFE SCIENCES

Description: VASP (vasodilator stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. Phosphorylation of VASP at Ser-157 causes a mobility shift in SDS gel electrophoresis from 46 to 50 kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity. VASP is the founding member of the Ena-VASP protein family, comprising the Drosophila protein Enabled (Ena), its mouse homologue Mena (mammalian Enabled), and mouse EVL (Ena-VASP-like protein). With these proteins VASP shares a conserved overall domain organization:
a) the conserved N-terminal Ena-VASP homology domain 1 (EVH1), which mediates binding to a proline-rich motif,
b) a more divergent proline-rich central domain (which is responsible for profilin binding), and
c) a conserved C-terminal EVH2 domain.

Particularly high VASP levels are present in platelets, although VASP is expressed in a wide variety of cell types and tissues. In cultured cells, VASP is associated with focal adhesions, cell-cell contacts, microfilaments, and highly dynamic membrane regions. From in vitro binding data VASP has been suggested to link profilin to zyxin, vinculin, and the Listeria spp. surface protein ActA, respectively. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation and the actin-dependent motility of intracellular bacterial pathogens.

UOM: 1 * 50 µG

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Catalog Number: (ENZOALX804180C100)

Supplier: ENZO LIFE SCIENCES

Description: The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804213R100)

Supplier: ENZO LIFE SCIENCES

Description: Mammalian apurinic/apyrimidinic (AP) endonuclease (APE1; APEX; HAP1; Ref-1) is a multifunctional, bipartite enzyme that belongs to the class II AP endonucleases and that plays an important role in numerous, cellular functions, like repairing abasic sites (loss of purine or pyrimidine base) in DNA, regulating the redox state of other proteins that play roles in oxidative signalling, transcription factor regulation (Fos, Jun, NF-κ B, Myb, HIF-1α, CREB, Pac), cell cycle control (p53) and apoptosis. APE1 initiates the DNA base excision repair (BER) by cleaving the DNA immediately adjacent to the 5’ of an AP site to produce a hydroxyl group at the 3’ terminus of an unmodified nucleotide upstream of the nick and a 5’-deoxyribose phosphate moiety downstream. The product of APE1 is further processed by DNA polymerase β to release 5’-deoxyribose phosphate with its intrinsic lyase activity. The nicked DNA is then sealed by DNA ligase I or DNA ligaseIII/XRCC1 to complete this repair process. In addition to the AP endonuclease activity, APE1 also possesses a 3’-5’ DNA exonuclease activity, a 3’-phosphodiesterase activity, a 3’-phosphatase activity, and a RNase H activity. It has been shown that APE1 is capable of excision L-configuration deoxyribonucleoside analogs from the 3’ termini of DNA. Human APE1 gene is located on chromosome 14q 11.2-12.

UOM: 1 * 100 µl

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Catalog Number: (ENZOALX804244C100)

Supplier: ENZO LIFE SCIENCES

Description: RANKL (TRANCE, OPGL, ODF) is a member of the TNF family. RANKL (receptor activator of NF-κB ligand) or TRANCE (TNF-related activation-induced cytokine receptor) has been implicated in interactions between T cells and dendritic cells. RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. RANKL is also important in T- and B-cell maturation. As OPGL (osteoprotegerin ligand) or ODF (osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. RANKL deficient mice show severe osteoporesis and complete abscence of osteoclasts as a result of lack of osteogenesis.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804277C100)

Supplier: ENZO LIFE SCIENCES

Description: Hepatitis C virus (HCV) is the primary cause of non-A, non-B hepatitis and results in most HCV-infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. The 21kDa core protein of HCV is well conserved among different HCV genotypes and may suppress hepatitis B virus replication in a phosphorylation dependent manner.

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: HDAC6 inhibitor

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