Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) is a chromatographic technique which uses a supercritical fluid as the mobile phase.  Although SFC has been around for some time, its adaptation as an orthogonal technique to HPLC, particularly in the pharmaceutical industry, has seen an increase over the last few years.  This interest has been fuelled by the increasing requirement for high throughput and a desire for ‘greener’ techniques. Large reductions in the use of solvents have significant benefits in terms of decreased sample processing and drying-down times, as well as providing cost and safety benefits.