You Searched For: STEMCELL Technologies

Catalog Number: (STMC05707)

Supplier: STEMCELL Technologies

Description: Kit for chemical dissociation of mouse neurospheres.

UOM: 1 * 1 KIT

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Supplier: STEMCELL Technologies

Description: Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi <i>et al.</i>). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause <i>et al.</i>), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. After LIF binds to the LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling (Auernhammer and Melmed; Suman <i>et al.</i>). LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype (Niwa <i>et al.</i>). Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment (Auernhammer and Melmed; Suman <i>et al.</i>). Human LIF can be used for the maintenance of mouse embryonic stem cells; however, mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive (Dahéron <i>et al.</i>). LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes (Metcalfe). LIF is also secreted by mesenchymal stromal cells, where it supports hematopoiesis and immune modulation (Nasef <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse, rhesus CD49f, APC-conjugated.

Catalog Number: (STMC75003)

Supplier: STEMCELL Technologies

Description: CFDA-SE (5(6)-carboxyfluorescein diacetate succinimidyl ester) is a stable, cell-permeable diacetate precursor to CFSE.

UOM: 1 * 10 mg

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Catalog Number: (STMC60021)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human CD56 (NCAM), unconjugated.

UOM: 1 * 100 µG

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Supplier: STEMCELL Technologies

Description: Animal component-free collagenase for the digestion of native collagen fibrils.

Catalog Number: (STMC60053)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgM antibody against human, mouse, rat oligodendrocyte marker O4, unconjugated.

UOM: 1 * 50 µG

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Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD4, PE-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD138 (syndecan-1), biotin-conjugated.

Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220).

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b, biotin-conjugated.

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD45, unconjugated.

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, FITC-conjugated.