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Catalog Number: (PRSI25-952)

Supplier: ProSci Inc.

Description: The exact function of PRRG1 remains unknown.

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-961)

Supplier: ProSci Inc.

Description: The exact function of C1orf95 remains unknown.

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-956)

Supplier: ProSci Inc.

Description: ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B4 is the plasma membrane calcium ATPase isoform 4.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

UOM: 1 * 50 µG

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Catalog Number: (PRSI26-541)

Supplier: ProSci Inc.

Description: SPRY1 belongs to the sprouty family. It contains 1 SPR (sprouty) domain. SPRY1 may function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

UOM: 1 * 50 µG

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Catalog Number: (PRSI26-539)

Supplier: ProSci Inc.

Description: ZNHIT3 contains 1 HIT-type zinc finger. The exact function of ZNHIT3 remains unknown.

UOM: 1 * 50 µG

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Catalog Number: (PRSI4417)

Supplier: ProSci Inc.

Description: Plxdc2 Antibody: Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.

UOM: 1 * 100 µG

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Catalog Number: (PRSI4421)

Supplier: ProSci Inc.

Description: ATG12 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

UOM: 1 * 100 µG

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Catalog Number: (PRSI4779P)

Supplier: ProSci Inc.

Description: IL-34 peptide is used for blocking the activity of IL-34 antibody.

UOM: 1 * 50 µG

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Catalog Number: (PRSI26-538)

Supplier: ProSci Inc.

Description: FHL3 contains 4 LIM zinc-binding domains. It is expressed only in skeletal muscle. FHL3 association with MyoD may contribute to the regulation of MyoD-dependent transcription of muscle genes and thereby myogenesis.LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.

UOM: 1 * 50 µG

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Catalog Number: (PRSI26-540)

Supplier: ProSci Inc.

Description: AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

UOM: 1 * 50 µG

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Catalog Number: (PRSI2081)

Supplier: ProSci Inc.

Description: ARC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

UOM: 1 * 100 µG

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Catalog Number: (PRSI2075)

Supplier: ProSci Inc.

Description: RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappa B and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1 beta. The messenger RNA of RICK is expressed in multiple human tissues.

UOM: 1 * 100 µG

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Catalog Number: (PRSI25-413)

Supplier: ProSci Inc.

Description: Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-418)

Supplier: ProSci Inc.

Description: SP4 belongs to the Sp1 C2H2-type zinc-finger protein family. It contains 3 C2H2-type zinc fingers. SP4 binds to GT and GC boxes promoters elements.It is a probable transcriptional activator.

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-424)

Supplier: ProSci Inc.

Description: TULP3 is a member of the tubby-like protein (TULP) family. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved C-terminal region of approximately 200 amino acid residues. The human and mouse TULP3 proteins share 69% amino acid sequence identity, with higher identity at the N and C termini than in the central region.This gene encodes a member of the tubby-like protein (TULP) family. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved C-terminal region of approximately 200 amino acid residues. The human and mouse TULP3 proteins share 69% amino acid sequence identity, with higher identity at the N and C termini than in the central region.

UOM: 1 * 50 µG

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Catalog Number: (PRSI26-583)

Supplier: ProSci Inc.

Description: DCLRE1C is a nuclear protein that is involved in V (D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). This gene encodes a nuclear protein that is involved in V (D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

UOM: 1 * 50 µG

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