You Searched For: Cayman Chemical

Supplier: Cayman Chemical

Description: Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A₂ (PLA₂) activity (IC₅₀=40 µM in human neutrophils).

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Supplier: Cayman Chemical

Description: ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).1 It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; Item No. 17753), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models.

Supplier: Cayman Chemical

Description: Hexadecanamide is a primary fatty acid amide that is derived from palmitic acid (C16:0) and belongs to a class of important cell signaling lipids.

Catalog Number: (CAYM25922-100)

Supplier: Cayman Chemical

Description: Anti-STING mouse monoclonal antibody [clone: 8E7]

UOM: 1 * 100 µG

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Supplier: Cayman Chemical

Description: Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Ethynyl estradiol is a synthetic analog of 17β-estradiol.

Supplier: Cayman Chemical

Description: Anti-Vtg Rabbit Polyclonal Antibody [clone: CS-2]

Catalog Number: (CAYM160862-1)

Supplier: Cayman Chemical

Description: Anti-iNOS Rabbit Polyclonal Antibody

UOM: 1 * 1 items

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Catalog Number: (CAYM160110-1)

Supplier: Cayman Chemical

Description: Anti-COX-1 Mouse Monoclonal Antibody [clone: CX111]

UOM: 1 * 1 items

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Supplier: Cayman Chemical

Description: Aminoguanidine hydrochloride

Supplier: Cayman Chemical

Description: The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific research today.

Catalog Number: (CAYM10007002-1)

Supplier: Cayman Chemical

Description: Anti-PTGDR2 Rabbit Polyclonal Antibody

UOM: 1 * 1 items

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Supplier: Cayman Chemical

Description: 4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine, pyridoxal, and pyridoxamine in and reduces growth of<i> S.</i> <i>carlsbergensis</i> cells. 4-DPD inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Supplier: Cayman Chemical

Description: Apigenin

Supplier: Cayman Chemical

Description: Benzimidazole

Catalog Number: (CAYM10010250-1)

Supplier: Cayman Chemical

Description: Anti-cRBP7 Rabbit Polyclonal Antibody

UOM: 1 * 1 items

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Catalog Number: (CAYM10009504-1)

Supplier: Cayman Chemical

Description: Anti-RAF-1 Rabbit Polyclonal Antibody

UOM: 1 * 1 items

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