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Supplier: STEMCELL Technologies

Description: Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch <i>et al.</i>). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete <i>et al.</i>). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson <i>et al.</i>). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz <i>et al.</i>; Yasuda <i>et al.</i>). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda <i>et al.</i>). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of regulatory T cells. IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Sonic hedgehog (Shh) is a member of the Hedgehog family of secreted signaling proteins that has a prominent role in patterning during early mammalian development (Ho and Scott). It is expressed during early embryogenesis in a variety of tissues (Finco <i>et al.</i>). During patterning of the central nervous system, Shh directly acts on cells to specify neural cell fates, regulates proliferation and survival of oligodendrocytes precursors and neural crest cells and stimulates proliferation, differentiation and axon growth (Ho and Scott; Martí). Shh also regulates T cell differentiation and activation (Crompton <i>et al.</i>). Recombinant human Shh (C24II; rhShh) is a fully biologically active molecule.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG1, kappa isotype control antibody, unconjugated.

Supplier: STEMCELL Technologies

Description: Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and <i>in vivo</i>. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets <i>in vivo</i>. TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 Ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock andamp; Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets.

Supplier: STEMCELL Technologies

Description: Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová and Hosek). Other effects of TNF-α include vasodilatation and edema formation.

Catalog Number: (STMC60069)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgM, kappa isotype control antibody, unconjugated.

UOM: 1 * 50 µG

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Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220), biotin-conjugated.

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, biotin-conjugated.

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, Pacific Blue™-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD62L (L-selectin), biotin-conjugated.

Catalog Number: (STMC60032)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse Sca1 (Ly-6A/E), unconjugated.

UOM: 1 * 500 µG

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Catalog Number: (STMC60149)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human CD10, unconjugated.

UOM: 1 * 0,1 mL

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Catalog Number: (STMC02692)

Supplier: STEMCELL Technologies

Description: Serum-free culture supplement for expansion of human erythroid cells.

UOM: 1 * 1 mL

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Catalog Number: (STMC01801)

Supplier: STEMCELL Technologies

Description: Membrane-permeable fluorescent probe for the detection of live neurons - 0,1 ml.

UOM: 1 * 0,1 mL

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