Anti-CD62L Rat Monoclonal Antibody [clone: MEL-14] (Biotin)

Supplier: STEMCELL Technologies
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60109BT 60109BT.1
STMC60109BTEA 341 GBP
STMC60109BT STMC60109BT.1
Anti-CD62L Rat Monoclonal Antibody [clone: MEL-14] (Biotin)
Antibodies
Rat monoclonal IgG2a antibody against mouse CD62L (L-selectin), biotin-conjugated.

  • T cells

The MEL-14 antibody reacts with murine CD62L (L-Selectin or LECAM-1), an ~74 - 95 kDa type I glycoprotein expressed on the surface of a majority of leukocytes. CD62L mediates leukocyte-endothelial cell interactions through its association with ligands such as CD34, glyCAM-1, MAdCAM-1 and PSGL-1. It functions to facilitate lymphocyte rolling on the vascular endothelium, trafficking of lymphocytes to the lymph nodes, and homing of lymphocytes and neutrophils to sites of inflammation. Murine CD62L is expressed on most thymocytes, the highest expression levels being found on subsets of immunocompetent or dividing progenitor cells, as well as on neutrophils, eosinophils, monocytes, and subsets of B, T and NK cells. The MEL-14 antibody may be used together with antibodies to other cell surface markers to distinguish naïve, memory and effector T cells. The MEL-14 antibody has been shown to block migration of lymphocytes to lymph nodes and to inhibit leukocyte rolling.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD62L
Clonality: Monoclonal
Clone: MEL-14
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse
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