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Image Unavailable-PRSI91-123

Human recombinant Flap Endonuclease 1 (from E. coli)

Catalog Number: (PRSI91-123)
Supplier: ProSci Inc.
Description: Flap Endonuclease 1 (FEN1) is a member of the XPG/RAD2 endonuclease family. During DNA replication, FEN1 cleaves the 5'-overhanging flap structure and processes the 5' ends of Okazaki fragments for synthesis. FEN1 also exhibits RNase H activity by possessing 5'-3' exonuclease activity on gapped double-stranded or nicked DNA, FEN1 is involved in the long patch base excision repair (LP-BER) pathway, it can cleave within the apurinic/apyrimidinic (AP) site-terminated flap. FEN1 can prevent flaps from equilibrating into structures that lead to duplications and deletions. FEN1 is also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
UOM: 1 * 50 µG
Image Unavailable-REGECP70051

EDTA Standard Solution 0,05 M

Catalog Number: (REGECP70051)
Supplier: REAGECON
Description: Reagecon's EDTA 0,05 M is a fully factorised, high purity, stable product, developed and tested for titrations. This is an analytical volumetric solution, also called titrant, standard titrant or standard solution. It is a reagent of known concentration, that is dispensed from a burette or other dispensing apparatus to a sample (analyte), until a reaction between the two liquids is judged to be complete. The product may be used for manual titrations, or more commonly automatic titrations also called potentiometric titration, to determine the end points by detection of any of several properties as detailed in several ChP monographs.
UOM: 1 * 1 L

New Product


Product Image-MILFLSKNS0500

Reagents for Montage® Plasmid Miniprep 96 Kits

Supplier: Merck
Description: Nucleic Acid Purification Kits and Reagents, RNase A, 0,9 ml

Image Unavailable-ENZOENZKIT1360250

gDNA Removal kit

Supplier: ENZO LIFE SCIENCES
Description: Rapid and complete removal of gDNA from RNA preps prior to reverse transcription.

Product Image-MILFLSKP09624

Montage® Plasmid Miniprep 96 Kits

Supplier: Merck
Description: Plasmid Miniprep 96 kit is a quick and easy-to-use kit that produces clean and reproducible DNA in half a time than traditional methods.

Product Image-ABCAAB283391-100

α-Amylase Inhibitor Screening Kit

Catalog Number: (ABCAAB283391-100)
Supplier: Abcam
Description: Simple, 1-step assay for screening potential α-amylase inhibitors.
UOM: 1 * 100 Tests
Image Unavailable-ENZOADIOSA400E

Anti-BVR Rabbit Polyclonal Antibody

Catalog Number: (ENZOADIOSA400E)
Supplier: ENZO LIFE SCIENCES
Description: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-10030R-FITC

Anti-LEO1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-10030R-FITC)
Supplier: Bioss
Description: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
UOM: 1 * 100 µl
Image Unavailable-M3292-00

Mag-Bind® Blood DNA HV Kit

Supplier: OMEGA BIO-TEK
Description: Isolate DNA from up to 10 ml blood using magnetic beads.

SDS

Product Image-K0512

Genomic DNA purification kit, Fermentas

Catalog Number: (K0512)
Supplier: Thermo Fisher Scientific
Description: DNA purification kit is a simple and rapid system for high quality genomic DNA purification from various sources including: whole blood, serum, cell lines, bacterial cells, plant, and mammalian tissues.
UOM: 1 * 1 KIT
Product Image-QUNT95213-010

Extracta Plus DNA kits

Supplier: Quantabio
Description: Rapid extraction and purification of high-quality total DNA from cultured cells or tissue.

Product Image-MILFLSKSBW500

Accessories for Montage® SEQ96 Sequencing Reaction Cleanup Kits

Supplier: Merck
Description: Nucleic Acid Purification Kits and Reagents, Montage® injection solution, 500 ml

Image Unavailable-BIOPSFS-SP0064

Real Time PCR Detection Test Kits, Supreme HLVd (Hop Latent Viroid)

Supplier: BIOPREMIER
Description: SUPREME RT-PCR detection kit HLVd is designed for the detection of Hop Latent Viroid (HLVd) in a single PCR reaction. The kit is suitable for use in real time instruments with FAM and Cy5 detection channels.

Product Image-D3485-01

E.Z.N.A.® Plant & Fungal DNA Kit

Supplier: OMEGA BIO-TEK
Description: Isolate DNA from plant or fungal samples using spin columns.

SDS Certificates

Product Image-MILFLSKS09601

Montage® SEQ96 Sequencing Reaction Cleanup Kits

Supplier: Merck
Description: The Montage® <sub>SEQ96</sub> sequencing reaction cleanup kit provides the filtration plate and solution necessary to remove contaminating salts and unincorporated dye terminators from DNA sequencing reactions.

Product Image-391-1255

VWR®, Adhesive PCR Film Seals

Supplier: VWR Collection
Description: These heat resistant 74,9 µm thick films are designed for thermal cycling applications. Polypropylene films are not pierceable. For PCR applications, where piercing with pipette tips or robotic probes is required for product recovery, use aluminium foil films. For real-time PCR applications, where maximum optical clarity is required, use optically-clear polyester films.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
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The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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