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Description: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Catalog Number: BOSSBS-13394R-A488
UOM: 1 * 100 µl
Supplier: Bioss


Description: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Catalog Number: BOSSBS-0837R-CY5
UOM: 1 * 100 µl
Supplier: Bioss


Description: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Catalog Number: BOSSBS-0837R-CY7
UOM: 1 * 100 µl
Supplier: Bioss


Description: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Catalog Number: BOSSBS-0837R-A647
UOM: 1 * 100 µl
Supplier: Bioss


Description: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Catalog Number: BOSSBS-0837R-A750
UOM: 1 * 100 µl
Supplier: Bioss


Description: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Catalog Number: BOSSBS-0837R-A488
UOM: 1 * 100 µl
Supplier: Bioss


Description: Toluene-[D₈] (99.5% D) for NMR spectroscopy
Catalog Number: 87159.0010
UOM: 1 * 10 mL
Supplier: VWR Chemicals

Description: Toluene ≥99.0%, GPR RECTAPUR®
Catalog Number: 28675.556
UOM: 1 * 200 L
Supplier: VWR Chemicals

Description: Toluene ≥99.7% (by GC, corrected for water content), ULTRA RESI-ANALYZED® for organic residue analysis, J.T.Baker®
Catalog Number: 9336.1000
UOM: 1 * 1 L
Supplier: Avantor

Description: Toluene ≥99.5% (by GC), AR® ACS, Macron Fine Chemicals™
Catalog Number: 8608-26
UOM: 1 * 200 L
Supplier: MACRON AVANTOR BRAND

Description: Toluene ≥99.7%, PESTINORM® for pesticide residue analysis
Catalog Number: 83664.320
UOM: 1 * 2,5 L
Supplier: VWR Chemicals

Description: Toluene ≥99.5% (by GC), AR®, Macron Fine Chemicals™
Catalog Number: 6784-45
UOM: 1 * 25 L
Supplier: MACRON AVANTOR BRAND

Description: Toluene, LiChrosolv® for HPLC, Supelco®
Catalog Number: 1.08327.1000
UOM: 1 * 1 L
Supplier: Merck

SDS


Description: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Catalog Number: BOSSBS-13394R-A680
UOM: 1 * 100 µl
Supplier: Bioss


Description: Toluene, anhydrous (max. 0.005% H₂O) ≥99.8%, AnalaR NORMAPUR® for synthesis
Catalog Number: 28681.295
UOM: 1 * 1 L
Supplier: VWR Chemicals

Description: Toluene ≥99%, GPR RECTAPUR® for pathology
Catalog Number: 28684.364
UOM: 1 * 5 L
Supplier: VWR Chemicals

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