Anti-CD45 Rat Monoclonal Antibody [clone: 30-F11]

Supplier: STEMCELL Technologies
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60030 60030.1
STMC60030EA 259 GBP
STMC60030 STMC60030.1
Anti-CD45 Rat Monoclonal Antibody [clone: 30-F11]
Antibodies
Rat monoclonal IgG2b antibody against mouse CD45, unconjugated.

  • Granulocytes
  • Subsets
  • Hematopoietic Stem
  • Progenitor cells
  • Lymphocytes
  • Myeloid cells

The 30-F11 antibody reacts with an extracellular epitope found on all isoforms and both alloantigens (CD45.1 and CD45.2) of mouse CD45, a type I transmembrane glycoprotein expressed on the surface of most hematopoietic cells except mature erythrocytes, platelets and plasma cells; expression of CD45 is lost during differentiation of these cell types. CD45 is a member of the protein tyrosine phosphatase family and functions in a number of immunoregulatory processes, including cell activation, growth, differentiation and oncogenic transformation. The large cytoplasmic portion of CD45 contains two tyrosine phosphatase domains, one which is enzymatically active, that are involved in modulating the function of intracellular substrates such as the Src kinases Lck and Fyn. Several isoforms of CD45 have been identified, the expression of which differs according to cell type and functional status. Alternative splicing of three exons (4, 5, 6) encoding the extracellular RA, RB and RC polypeptide sequences gives rise to up to 8 isoforms with molecular masses in the range of 180 - 240 kDa.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD45
Clonality: Monoclonal
Clone: 30-F11
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Mouse
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