Anti-CD48 (SLAMF2) Hamster Monoclonal Antibody [clone: HM48-1] (APC)

Supplier: STEMCELL Technologies
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60162AZ 60162AZ.1
STMC60162AZEA 371 GBP
STMC60162AZ STMC60162AZ.1
Anti-CD48 (SLAMF2) Hamster Monoclonal Antibody [clone: HM48-1] (APC)
Antibodies
Hamster (Armenian) monoclonal IgG1 antibody against mouse CD48 (SLAMF2), APC-conjugated.

  • B cells
  • Hematopoietic stem
  • Progenitor cells
  • Macrophages
  • Monocytes
  • T cells

The HM48-1 antibody reacts with mouse CD48, a 45 kDa GPI-anchored glycoprotein and a member of the signaling lymphocyte activation molecule (SLAM) family and Ig superfamily. SLAM family members play a role in multiple aspects of immune function including costimulation, cytotoxicity, and cytokine production. CD48 also plays a role in cell adhesion and T cell activation. In mice, CD48 is thought to be present on nearly all hematopoietic cells except neutrophils and ESLAM cells (CD45+EPCR+CD48-CD150+ hematopoietic stem cells with long-term self-renewal capacity). Ligands for CD48 include CD2 and CD244, binding of which helps to promote interactions between immune cells. HM48-1 is reported to be capable of blocking CD48:CD2 and CD48:CD244 interactions in vitro and in vivo. HM48-1 is also reported to inhibit the proliferative response of spleen cells to mitogens, inhibit CTL activity, and enhance the survival of cardiac allografts.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD48 (SLAMF2)
Clonality: Monoclonal
Clone: HM48-1
Conjugation: APC
Epitope:
Host: Hamster
Isotype: IgG1 lambda
Reactivity: Mouse
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