Anti-CD44 Rat Monoclonal Antibody [clone: IM7] (PE)

Supplier: STEMCELL Technologies
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STMC60068PE.1EA 88 GBP
STMC60068PE.1 STMC60068PE
Anti-CD44 Rat Monoclonal Antibody [clone: IM7] (PE)
Antibodies
Rat monoclonal IgG2b antibody against human, mouse, rhesus CD44 (tissue non-specific alkaline phosphatase), PE-conjugated.

  • Mammary cells
  • T cells

The IM7 antibody reacts with CD44 (Ly-24), an ~80 - 95 kDa type 1 transmembrane glycoprotein involved in cell-cell and cell-matrix interactions. CD44 is expressed on the surface of many cells, including leukocytes and hepatocytes, as well as endothelial, epithelial, and mesenchymal cells. Expression levels increase upon activation of T and B cells, and memory cells exhibit a CD44high phenotype. CD44 binds many ligands, including hyaluronic acid, collagen, fibronectin, growth factors, and metalloproteinases, thus modulating processes such as lymphocyte activation, recirculation and homing, leukocyte rolling and aggregation, hematopoiesis, and tumor metastasis. Numerous disorders are associated with altered expression or dysfunction of CD44. Many CD44 isoforms have been identified, with alternative splicing, differential N- and O- glycosylation, and sulfation mediating the functional role(s) played by the protein in a specific cell. The IM7 monoclonal antibody reacts with an extracellular epitope found on all isoforms of CD44 and both murine allotypes. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse CD4+ T Cell Isolation Kit (Catalog #19852), EasySep™ Mouse CD4+CD62L+ T Cell Isolation Kit (Catalog #18765), and EasySep™ Human Naïve CD4+ T Cell Isolation Kit (Catalog #19555).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD44
Clonality: Monoclonal
Clone: IM7
Conjugation: PE
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Baboon, Cat, Chimpanzee, Bovine, Cynomolgus monkey, Dog, Horse, Human, Mouse, Pig, Rhesus monkey, Squirrel monkey
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