Antibiotics & Antimycotics
Antibiotics and Antimycotics
Antibiotics and Antimycotics are a type of antimicrobial drug used in the treatment and prevention of bacterial infections. They may either kill or inhibit the growth of microorganisms.
In science, antibiotics and antimycotics are mostly used in cell culture. They are used to select for a specific type of cells, either when cultivating mammal cells to exclude bacteria or when selecting for genetically modified cells which carry a resistance gene.
PanReac AppliChem antibiotics and antimycotics can be used for small assays and larger scale applications. Here, you can find a selection of the most commonly used products from this range.
Ensure reproducibility for your cell culture or microbiology experiments with PanReac AppliChem antibiotics and antimycotics.
List of selected antibiotics:
| Product No. | Description | Target organism |
Mode of action |
Recommended working concentration |
Stock solution |
| Amphotericin B |
fungi, yeast |
binds to sterols with planar structure and impairs with membrane permeability |
0.25 µg/ml |
30-40 mg/ml in DMSO |
|
| Blasticidin S hydrochloride |
Prokaryotes, Eukaryotes |
inhibits protein biosynthesis by preventing the formation of the peptide bond |
3-100 µg/ml |
50 mg/ml in H2O or buffer store at +4°C - -20°C |
|
| Carbenicillin disodium salt |
gram negative germs, enterococci |
inhibits cell wall synthesis (transpeptidase) in growing bacteria |
20-60 µg/ml |
50 mg/ml in H2O/MeOH 1:1 store at -20°C |
|
| Cycloheximide (Actidion) |
fungi, eukaryotes |
binds to 80 S ribosome in eukaryotic cells; inhibits formation of peptide bond |
10 µg/ml |
10 mg/ml |
|
| Gentamycin sulfate |
gram positive/ negative germs |
inhibits protein synthesis by binding to the L6 protein of the 50 S ribosomal subunit |
15-50 µg/ml |
10-20 mg/ml in water, formamide |
|
| Hygromycin B - Solution |
10-400 µg/ml |
ca. 41 mg/ml in H2O; store at -20°C |
|||
| Kanamycin sulfate & Kanamycin Sulfate (Ph. Eur., BP) pure, pharma rade |
gram positive/ |
inhibits protein synthesis (translocation) |
10-100 µg/ml |
10 mg/ml in H2O |
|
| Polymyxin B sulfate |
gram negative bacteria - non- proliferating germs too |
interaction with phospholipid components of the bact. cell membrane; changes permeability of the membrane and causes efflux of essential plasma compounds |
50 µg/ml |
25 mg/ml H2O, MeOH |
|
| Vancomycin hydrochloride |
bacteriostatic and bacterizide against gram positive cocci and bacteria |
amphoteric glyopeptide antibiotic; binds to bacterial cell wall precursors (peptidoglycans) |
1-25 µg/ml |
soluble in water ›100 mg/ml |