You Searched For: STEMCELL Technologies

Supplier: STEMCELL Technologies

Description: Epidermal growth factor (EGF) is the founding member of the EGF family of proteins and is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). EGF can stimulate the proliferation of mouse embryonic stem cells or induce the terminal differentiation/growth inhibition of A431 cells (Heo <i>et al.</i>).

Catalog Number: (STMC60128)

Supplier: STEMCELL Technologies

Description: Rabbit polyclonal antibody against human, mouse, rat GFAP (glial fibrillary acidic protein), unconjugated.

UOM: 1 * 200 µl

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Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of untouched human total lymphocytes

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T regulatory cells, as well as mast cells, NK cells, neutrophils, and regulatory B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the activation of certain immune cells while it promotes the function of B cells, and facilitate healing process. Specifically, this cytokine is important for the function of T regulatory cells as it is a potent suppressor of effector T cell proliferation and cytokine production. Also, IL-10 produced by a subset of macrophages inhibits activation and production of pro-inflammatory cytokines by neighboring macrophages, thus allowing a level of self-regulation. IL-10 enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression (Ouyang <i>et al.</i>).

Catalog Number: (STMC60027)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse F4/80, unconjugated.

UOM: 1 * 500 µG

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Catalog Number: (STMC04536)

Supplier: STEMCELL Technologies

Description: Serum-free methylcellulose-based medium with recombinant cytokines (without EPO) for human cells.

UOM: 1 * 100 mL

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Catalog Number: (STMC03774)

Supplier: STEMCELL Technologies

Description: Methylcellulose-based medium with recombinant cytokines (without EPO) for rat cells.

UOM: 1 * 100 mL

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Catalog Number: (STMC78083.1)

Supplier: STEMCELL Technologies

Description: Interleukin 6 receptor (IL-6R) alpha is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6. IL-6 binds to the membrane-bound non-signaling IL-6R alpha (mIL-6R), and the complex binds to two molecules of gp130 and leads to ‘classical’ IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways (Scheller <i>et al.</i>). In contrast, a soluble form of IL-6R alpha (sIL-6R), which comprises the extracellular portion of the receptor, binds to the secreted IL-6 to form a complex that promotes bioavailability of IL-6. The complex of IL-6 and sIL-6R can bind to gp130 on cells that do not express the IL-6R and are unresponsive to IL-6. This process is known as trans-signaling (Hunter and Jones; Rose-John S). sIL-6R regulates both local and systemic IL-6-mediated events. Elevated levels of sIL-6R have been documented in several disease conditions such as rheumatoid arthritis, myeloma, and Crohn’s disease (Jones <i>et al.</i>; Mihara <i>et al.</i>).

UOM: 1 * 50 µG

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Supplier: STEMCELL Technologies

Description: Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that belongs to the four-helix bundle cytokine family and is structurally related to interleukin 6 (IL-6), interleukin 11 (IL-11), leukemia inhibitory factor (LIF), and oncostatin M (OSM). CNTF binds to its receptor CNFTRα and induces formation of a heterodimer of the signal-transducing IL-6 receptor gp130 and LIF receptor (LIFR)-β, which triggers JAK/STAT, ERK, and the PI3K signaling cascades (Schuster <i>et al.</i>). CNTF plays an important role in neurogenesis and the differentiation of neural stem cells and has been suggested to possess a therapeutic role in treating neurological disorders (Ding <i>et al.</i>; Oppenheim <i>et al.</i>). CNTF has also been shown to protect rod photoreceptors from light-induced damage and to have therapeutic effects on retinal degenerative diseases caused by genetic defect or damage induced by toxins, autoantibodies, or strong light (Pernet <i>et al.</i>; Rhee <i>et al.</i>). Another therapeutic role of CNTF has been reported in protecting oligodendrocytes from death induced by apoptosis (Louis <i>et al.</i>). Additionally, CNTF is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into astrocytes (Krencik and Zhang).

Catalog Number: (STMC60142)

Supplier: STEMCELL Technologies

Description: Rabbit polyclonal antibody against human, mouse phosphoSHIP, unconjugated.

UOM: 1 * 100 µl

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Catalog Number: (STMC60139FI)

Supplier: STEMCELL Technologies

Description: Goat polyclonal antibody against mouse IgM (heavy chain), FITC-conjugated.

UOM: 1 * 1 mg

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Catalog Number: (STMC15382)

Supplier: STEMCELL Technologies

Description: Immunodensity enrichment of untouched human ILC2s.

UOM: 1 * 1 KIT

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Catalog Number: (STMC60129AV)

Supplier: STEMCELL Technologies

Description: Goat polyclonal antibody against rabbit IgG (H+L), AMCA-conjugated.

UOM: 1 * 1,5 mg

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Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of CD11b+ cells (e.g. monocytes) from mouse splenocytes or other tissues.

Catalog Number: (STMC07070)

Supplier: STEMCELL Technologies

Description: Dye for staining mouse mammary gland whole mounts.

UOM: 1 * 100 mL

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