You Searched For: ProSci Inc.

Catalog Number: (PRSI38-119)

Supplier: ProSci Inc.

Description: Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. In contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons.

UOM: 1 * 100 µG

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Catalog Number: (PRSI38-117)

Supplier: ProSci Inc.

Description: MCP 2 is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. MCP 2 is important to inflammatory host responses, and is found in the highest concentration in the small intestine and peripheral blood cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI38-132)

Supplier: ProSci Inc.

Description: IL19 is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Little is known about the biologic function and gene regulation of IL19.

UOM: 1 * 50 µG

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Catalog Number: (PRSI45-140)

Supplier: ProSci Inc.

Description: Anti-RXRB Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI30-047)

Supplier: ProSci Inc.

Description: IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

UOM: 1 * 100 µG

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Catalog Number: (PRSI30-046)

Supplier: ProSci Inc.

Description: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine.Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

UOM: 1 * 50 µG

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Catalog Number: (PRSI29-999)

Supplier: ProSci Inc.

Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

UOM: 1 * 100 µG

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Catalog Number: (PRSI30-058)

Supplier: ProSci Inc.

Description: PLP2 may play a role in cell differentiation in the intestinal epithelium.

UOM: 1 * 100 µG

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Catalog Number: (PRSI39-861)

Supplier: ProSci Inc.

Description: Cavin 3 SRBC (Serum deprivation response factor-related gene product that binds to C-kinase) is a member of PKCdelta-binding protein. Immunolocalization studies show Cavin 3 in caveoli. Cavin 3 appears to be recruited to caveoli by Cavin 1 and 2 where it forms a complex.

UOM: 1 * 100 µG

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Catalog Number: (PRSI39-869)

Supplier: ProSci Inc.

Description: Kynurenine 3-monooxygenase (KMO) catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). The enzyme is required for synthesis of quinolinic acid. Quinolinic acid ia a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development.

UOM: 1 * 100 µG

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Catalog Number: (PRSI39-867)

Supplier: ProSci Inc.

Description: Janus Kinase 2 (JAK2) is essential for signaling thorough a variety of cytokine receptors. Phosphorylation of JAK is essential for downstream signaling. JAK kinases are known to phosphorylate several substrate including members of the STAT family of proteins

UOM: 1 * 50 µG

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Catalog Number: (PRSI39-873)

Supplier: ProSci Inc.

Description: STIM-1 is a component of the Ca sensor/channel. It associates with ORAI-1 and form a essential complex involved in store-operated channels. STIM1 activates Ca(2+) influx via Orai1 channels. Expression of STIM and Orai proteins are found in many cell types and knock-out mice lack viability.

UOM: 1 * 100 µG

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Catalog Number: (PRSI39-866)

Supplier: ProSci Inc.

Description: Janus Kinase 2 (JAK2) is essential for signaling thorough a variety of cytokine receptors. Phosphorylation of JAK is essential for downstream signaling. JAK kinases are known to phosphorylate several substrate including members of the STAT family of proteins

UOM: 1 * 50 µG

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Catalog Number: (PRSI39-860)

Supplier: ProSci Inc.

Description: Cavin 2-SDR (serum deprivation response) is a member of the PKC enzyme family. Immunolocalization studies show Cavin 2 in caveoli. Cavin 2 appears to be recruited to caveoli by Cavin 1. Cavin 2 appears to be involved in some aspects of caveolar function yet to be determined

UOM: 1 * 100 µG

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Catalog Number: (PRSI37-144)

Supplier: ProSci Inc.

Description: Anti-TNFSF11 Rat Monoclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI45-777)

Supplier: ProSci Inc.

Description: Anti-ITGB5 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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