You Searched For: ProSci Inc.

Catalog Number: (PRSI28-335)

Supplier: ProSci Inc.

Description: This intronless gene, SOX14, encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in the SOX14 gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome.

UOM: 1 * 100 µG

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Catalog Number: (PRSI28-317)

Supplier: ProSci Inc.

Description: CACNB2 is a member of the ion-channel gene superfamily. Described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, this gene is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS.

UOM: 1 * 100 µG

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Catalog Number: (PRSI42-889)

Supplier: ProSci Inc.

Description: Anti-DEFB119 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI28-328)

Supplier: ProSci Inc.

Description: ZNF45 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 18 C2H2-type zinc fingers and 1 KRAB domain. ZNF45 may be involved in transcriptional regulation.

UOM: 1 * 50 µG

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Catalog Number: (PRSI42-872)

Supplier: ProSci Inc.

Description: Anti-TSHR Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-737)

Supplier: ProSci Inc.

Description: cDNA sequence of HSZFP36 is generated by Mammalian Gene Collection (MGC) Program Team.

UOM: 1 * 50 µG

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Catalog Number: (PRSI36-037)

Supplier: ProSci Inc.

Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.

UOM: 1 * 100 µG

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Catalog Number: (PRSI36-036)

Supplier: ProSci Inc.

Description: IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

UOM: 1 * 100 µG

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Catalog Number: (PRSI36-039)

Supplier: ProSci Inc.

Description: ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.

UOM: 1 * 50 µG

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Catalog Number: (PRSI36-040)

Supplier: ProSci Inc.

Description: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-157)

Supplier: ProSci Inc.

Description: USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. It deubiquitylates histone H2A in addition to H2B. Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer.

UOM: 1 * 50 µG

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Catalog Number: (PRSI27-154)

Supplier: ProSci Inc.

Description: SMARCD1 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. It is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 50 µG

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Catalog Number: (PRSI27-153)

Supplier: ProSci Inc.

Description: NPM2 belongs to the nucleoplasmin family. It probably involved in sperm DNA decondensation during fertilization.

UOM: 1 * 50 µG

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Catalog Number: (PRSI27-150)

Supplier: ProSci Inc.

Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. H2AFX is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UOM: 1 * 50 µG

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Catalog Number: (PRSI71-048)

Supplier: ProSci Inc.

Description: Anti-IVL Rabbit Polyclonal Antibody

UOM: 1 * 250 µl

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Catalog Number: (PRSI79-339)

Supplier: ProSci Inc.

Description: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

UOM: 1 * 100 µG

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