You Searched For: ProSci Inc.

Catalog Number: (PRSI16-952)

Supplier: ProSci Inc.

Description: Anti-GADD45A Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI22-159)

Supplier: ProSci Inc.

Description: Anti-CLIC1 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI60-063)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI18-251)

Supplier: ProSci Inc.

Description: Anti-PRDX3 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI64-229)

Supplier: ProSci Inc.

Description: Anti-ATG5 Rabbit Monoclonal Antibody [clone: 1358CT289.125.123]

UOM: 1 * 100 µl

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Catalog Number: (PRSI57-234)

Supplier: ProSci Inc.

Description: Anti-MBL2 Rabbit Polyclonal Antibody

UOM: 1 * 400 µl

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Catalog Number: (PRSI80-018)

Supplier: ProSci Inc.

Description: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-996)

Supplier: ProSci Inc.

Description: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

UOM: 1 * 100 µG

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Catalog Number: (PRSI80-025)

Supplier: ProSci Inc.

Description: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

UOM: 1 * 100 µG

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Catalog Number: (PRSIXP-5156)

Supplier: ProSci Inc.

Description: Anti-IFNG Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSIXP-5151)

Supplier: ProSci Inc.

Description: Anti-CCL14 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSIXP-5155)

Supplier: ProSci Inc.

Description: IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains

UOM: 1 * 100 µG

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Catalog Number: (PRSI92-611)

Supplier: ProSci Inc.

Description: S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in grey matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in human melanocytes, is a reliable marker for melanoma malignancy both in biotic tissue and in serum.

UOM: 1 * 50 µG

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Catalog Number: (PRSI92-607)

Supplier: ProSci Inc.

Description: Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumours.

UOM: 1 * 50 µG

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Catalog Number: (PRSI30-340)

Supplier: ProSci Inc.

Description: NANOG is a new marker for testicular carcinoma in situ and germ cell tumors. Gene knockdown of Nanog promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal.

UOM: 1 * 50 µG

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Catalog Number: (PRSI42-996)

Supplier: ProSci Inc.

Description: Anti-TNFRSF1A Goat Polyclonal Antibody

UOM: 1 * 100 µG

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