Description: Host: Rabbit

Catalog Number: ENZOBMLSA4820025

UOM: 1 * 25 µl

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Rabbit

Catalog Number: ENZOBMLSA5100200

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Rabbit

Catalog Number: ENZOBMLSA5120100

UOM: 1 * 100 µl

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Rabbit

Catalog Number: ENZOBMLSA5090100

UOM: 1 * 100 µl

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: The human Cullin family of genes consists of Cul-1, Cul-2, Cul-3, Cul-4a, Cul-4b, and Cul-5. Among the 6 members, Cul-1 and Cul-2 are very well characterized. Cul-2 is homologous to the Saccharomyces cerevisiae cdc53 gene. Studies have shown that Cul-1 forms an E3 ubiquitin-ligase, called the SCF complex (Skp1 and F-box protein such as bTrCp or FWD1), which controls the proteolysis of G1 cell cycle regulatory proteins.

Catalog Number: ENZOADIKAMCC135D

UOM: 1 * 50 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Rabbit

Catalog Number: ENZOALX210952C100

UOM: 1 * 100 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Clear plates designed for ELISA and colorimetric detection.

Catalog Number: ENZOADI800144

UOM: 1 * 1 items

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770.

Catalog Number: ENZOADINBA100E

UOM: 1 * 100 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Catalog Number: ENZOADIKASNO001F

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Catalog Number: ENZOADISPA894F

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.

Catalog Number: ENZOADISPA901F

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Mouse, Isotype: IgG1

Catalog Number: ENZOENZ30904

UOM: 1 * 6 mL

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: IgE Antibody

Catalog Number: ENZOBPDDIAHE11

UOM: 1 * 1 mg

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Host: Mouse, Isotype: IgG1

Catalog Number: ENZOENZ30932

UOM: 1 * 6 mL

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Hsp40/Hdj1 is a cytosolic co-chaperone belonging to the class DnaJ, named after its homolog in E. coli. Hsp40 functions in protein folding by binding nascent peptides and unfolded substrates and facilitating substrate interaction with Hsp70. Binding of Hsp40 to Hsp70 increases Hsp70 ATP hydrolysis and substrate binding, which is reversed by the action of nucleotide exchange factors (GrpE in E. coli). Repeated cycles of Hsp40/Hsp70 peptide binding and ATP hydrolysis prevent premature folding and aggregation, promoting protein maturation throughout the cell.

Catalog Number: ENZOADISPA400F

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale

Description: Chaperonin 10 (Cpn10 or Hsp10), is the ~10 kDa mammalian equivalent to GroES of <i>E. coli</i>. Chaperonins play fundamental roles in the folding, assembly, and translocation of other proteins.

Catalog Number: ENZOADISPA110F

UOM: 1 * 200 µG

Supplier: ENZO LIFE SCIENCES

New Product Sale