You Searched For: ENZO LIFE SCIENCES

Catalog Number: (ENZOENZABS2460100)

Supplier: ENZO LIFE SCIENCES

Description: Recommended Applications: Flow Cytometry

Species reactivity: Human

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905762100)

Supplier: ENZO LIFE SCIENCES

Description: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905685100)

Supplier: ENZO LIFE SCIENCES

Description: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905683100)

Supplier: ENZO LIFE SCIENCES

Description: The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905799100)

Supplier: ENZO LIFE SCIENCES

Description: The opioid receptors delta (DOP, OP1), kappa (KOP, OP2), and mu (MOP, OP3) are members of the seven-transmembrane domain-containing receptor family of G-protein coupled receptors, sharing nearly 60% identity, but varying greatly in the extracellular N-terminus region of the receptors. The delta, kappa and mu-receptors serve as functional receptors for endogenous enkephalin, dynorphin, and beta-endorphin peptide ligands, respectively, mediating their signal via coupling to Gi/o alpha subunits to inhibit adenylyl cyclases and calcium conductance (N- and L-type channels), and to stimulate MAPK activation and potassium conductance. Delta-opioid receptors are highly expressed in the olfactory bulb, neocortex, caudate putamen and nucleus accumbens, with peripheral expression in the gastro-intestinal tract and vas deferens. Delta-opioid receptors function to inhibit neurotransmitter release resulting in a variety of biological effects including analgesia, motor integration, gastro-intestinal motility, olfaction,

UOM: 1 * 100 µG

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Catalog Number: (ENZOBPDABS06368B01)

Supplier: ENZO LIFE SCIENCES

Description: Recommended Applications: ELISA, IHC

Species reactivity: Rhesus monkey, Cynomolgus

UOM: 1 * 150 µG

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Catalog Number: (ENZOADICSA514E)

Supplier: ENZO LIFE SCIENCES

Description: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADIAAM149E)

Supplier: ENZO LIFE SCIENCES

Description: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterized by the presence of at least one Bcl-2 homology (BH) domains. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes where it inserts and mediates the release of cytochrome c. This activates caspase-3 and perpetuates the apoptotic cascade.

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Catalog Number: (ENZOADICSA509E)

Supplier: ENZO LIFE SCIENCES

Description: SARM (SAM and ARM-containing protein) is thought to serve as an adaptor protein for the Toll-like receptors (TLRs) and allow for the activation of downstream kinases and NF-κB, ultimately leading to the expression of proteins involved in host defense.

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: Host: Rat, Isotype: IgG2a

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Catalog Number: (ENZOALX804016R100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Catalog Number: (ENZOALX804126C100)

Supplier: ENZO LIFE SCIENCES

Description: Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX803017R100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Catalog Number: (ENZOALX804040C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804099R100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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