You Searched For: SIELC+TECHNOLOGIES

Supplier: THERMO MATRIX TECHNOLOGIES

Description: These disposable automation reservoirs made of PP offer excellent chemical resistance. The reservoirs feature the same shape and dimensions as standard microplates, giving users the flexibility to handle reagents on virtually any automated liquid handler.

Sale

Supplier: THERMO MATRIX TECHNOLOGIES

Description: PP. 96-well plates for sample storage.

Supplier: THERMO MATRIX TECHNOLOGIES

Description: PP or PS. These reservoirs offer an extra-wide base to add rigidity and stability, helping to avoid spills.

Sale

Catalog Number: (736-0198)

Supplier: THERMO MATRIX TECHNOLOGIES

Description: PP. The square well geometry of this 96-well plate makes it ideal for bacterial growth applications.

UOM: 1 * 50 items

Certificates Sale

Supplier: BW TECHNOLOGIES

Description: Single gas detectors for safety and compliance in harsh environments with extreme temperatures.

Supplier: THERMO MATRIX TECHNOLOGIES

Description: Easy Peel, Microplate seal for ALPS 50V, Heat sealing film/foil/tape (96/384 wells), Single sheet/mat/strip, Film, heat sealing, Easy Peel film laminate

Supplier: THERMO MATRIX TECHNOLOGIES

Description: 96-well PP plates with square wells for storage and screening applications, as well as growth of bacterial cultures when used in conjuction with gas permeable adhesive seals.

Supplier: Primera Technology Europe

Description: Ribbons come in Standard, TC1 or TC2 quality.

Supplier: THERMO MATRIX TECHNOLOGIES

Description: PP, translucent

Catalog Number: (STMC100-1081)

Supplier: STEMCELL Technologies

Description: Goat polyclonal antibody against mouse IgG (H+L).

UOM: 1 * 200 µG

Sale

 This is a MarketSource item. Additional charges may apply

Catalog Number: (STMC100-1403)

Supplier: STEMCELL Technologies

Description: Stimulating T cells with HHV8 (K8) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV8 (K8) peptide pool is a lyophilised mixture of 57 peptides from protein K8 alpha of human herpesvirus 8 (HHV-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 237 on K8. A basic leucine zipper (bZip) protein that associates with the lytic origin of HHV8 (Lin <i>et al.</i>), K8 is thought to play a role in lytic DNA replication, as a trans-acting factor (AuCoin <i>et al.</i>). It has also been found to modulate the activity of the transcriptional transactivator K-Rta (Izumiya <i>et al.</i>), and has an autoregulatory function (Wang <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 AU

New Product Sale

 This is a MarketSource item. Additional charges may apply

Supplier: STEMCELL Technologies

Description: Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).

New Product

Supplier: STEMCELL Technologies

Description: Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-κB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immunosuppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová andamp; Hosek). Other effects of TNF-α include vasodilatation and edema formation.

New Product

Catalog Number: (STMC78027.2)

Supplier: STEMCELL Technologies

Description: Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford <i>et al.</i>). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford <i>et al.</i>).

UOM: 1 * 1.000 µG

New Product Sale

 This is a MarketSource item. Additional charges may apply

Supplier: STEMCELL Technologies

Description: Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld <i>et al.</i>). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine <i>et al.</i>). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh <i>et al.</i>; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine <i>et al.</i>). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan <i>et al.</i>).

New Product

Supplier: STEMCELL Technologies

Description: Interleukin 13 (IL-13) is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) (Pulendran and Artis). IL-13 binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2 (Wynn 2003). IL-13 receptor is expressed on B cells and promotes B cell proliferation, induces class switching to IgG4 and IgE, and functions in the recruitment and activation of IgE-producing B cells (Hershey). The receptor is also expressed on basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells (Hershey). Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. <i>in vivo</i>, IL-13 has a role in resistance to extracellular helminth parasites by regulating gastrointestinal parasite expulsion, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis (Wynn 2015). Secreted IL-13 is a protein consisting of 112 amino acids with a molecular mass of 10 kDa (Hershey). Human IL-13 is not species-specific but has greater activity on human cells compared to mouse cells (Hershey).

New Product