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Human recombinant Ldlr1 (from HEK293 cells)

Catalog Number: (PRSI96-509)

Supplier: ProSci Inc.

Description: Low-Density Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.

UOM: 1 * 100 µG

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Tube clamps, Pure-Fit® TCL

Supplier: Saint Gobain Life Sciences

Description: Pure-Fit® TCL large tube clamps provide the same innovative clamping technology as Pure-Fit TC but are designed to accommodate large diameter and thick wall tubing applications.

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Microplate Clamp for VWR® Standard and Advanced Shakers

Catalog Number: (444-2954)

Supplier: VWR Collection

Description: Attaches to the relevant universal platform being used with the shaker. For details of universal platforms please see the relevant entries.

UOM: 1 * 1 items

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VWR®, Clamps, Three Pronged

Catalog Number: (241-0015)

Supplier: VWR Collection

Description: Laboral aluminium alloy.

UOM: 1 * 5 items

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Clamps for universal platforms, MaxQ™ 8000

Supplier: Thermo Fisher Scientific

Description: Clamp, Flask Clamp Starter Kit, includes microplate clamp, 25 ml flask clamps, 50 ml flask clamps, 125 ml flask clamps, 250/300 ml flask clamps, 500 ml flask clamps, 1 l flask clamps, 2 l flask clamps and replacement screws, For: MaxQ™ 8000