You Searched For: WYE-125132


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Supplier: ENZO LIFE SCIENCES
Description: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

New Product

Supplier: Cayman Chemical
Description: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC<sub>50</sub> = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both <i>in vitro</i> and <i>in vivo</i>. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.

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Supplier: ENZO LIFE SCIENCES
Description: Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.

New Product

Supplier: ENZO LIFE SCIENCES
Description: Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.

New Product

Supplier: Saint Gobain Life Sciences
Description: Pure-Fit SIB eliminates entrapment and leak points that can occur with traditional assembly systems. The unique internal design eliminates voids or dead space that can lead to turbulence or stagnation of fluid flow creating the potential for bacterial growth.

Supplier: Saint Gobain Life Sciences
Description: Pure-Fit SIB eliminates entrapment and leak points that can occur with traditional assembly systems. The unique internal design eliminates voids or dead space that can lead to turbulence or stagnation of fluid flow creating the potential for bacterial growth.

Catalog Number: (MFLX00336-NY)
Supplier: Avantor Fluid Handling
Description: CFLX WYE ASSEMBLY W 374 125 2 1 * 1 items
UOM: 1 * 1 items


Catalog Number: (SIALPZ0321-5MG)
Supplier: Merck
Description: WYE-125132 1 * 5 mg
UOM: 1 * 5 mg


Catalog Number: (SIALPZ0321-25MG)
Supplier: Merck
Description: WYE-125132 1 * 25 mg
UOM: 1 * 25 mg


Catalog Number: (MDEXHY-10044-10MG)
Supplier: MEDCHEMEXPRESS
Description: WYE-132 [1144068-46-1] 1 * 10 mg
UOM: 1 * 10 mg

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (CAYM29977-5)
Supplier: Cayman Chemical
Description: WYE-687 1 * 5 mg
UOM: 1 * 5 mg


Catalog Number: (CAYM29977-25)
Supplier: Cayman Chemical
Description: WYE-687 1 * 25 mg
UOM: 1 * 25 mg


Catalog Number: (CAYM29977-1)
Supplier: Cayman Chemical
Description: WYE-687 1 * 1 mg
UOM: 1 * 1 mg


Catalog Number: (CAYM13604-10)
Supplier: Cayman Chemical
Description: WYE-354 (10 mg) 1 * 10 mg
UOM: 1 * 10 mg


Catalog Number: (CALB475986-5MG)
Supplier: Merck Millipore (Calbiochem‎)
Description: mTOR Kinase Inhibitor II, WYE-354 1 * 5 mg
UOM: 1 * 5 mg


Catalog Number: (CAYM13604-25)
Supplier: Cayman Chemical
Description: WYE-354 (25 mg) 1 * 25 mg
UOM: 1 * 25 mg


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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