WYE-125132 ≥98%, crystalline solid

Supplier: Cayman Chemical
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

18372-1 18372-10 18372-5 18372-500
CAYM18372-1EA 203 GBP
CAYM18372-1 CAYM18372-10 CAYM18372-5 CAYM18372-500
WYE-125132 ≥98%, crystalline solid
WYE-125132

WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.

MW: 519.6 g/mol
MDL Number: MFCD22420813
CAS Number: 1144068-46-1

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR