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Tyrphostin AG-126

Supplier: Apollo Scientific
Description: MAPK/ERK Signalling Pathway

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Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

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Tyrphostin AG 527 ≥98% (by HPLC)

Catalog Number: (ENZOALX270141M025)
Supplier: ENZO LIFE SCIENCES
Description: Tyrphostin AG 527 ≥98% (by HPLC)
UOM: 1 * 25 mg

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Tyrphostin AG 490 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

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Tyrphostin AG 1024 ≥98% (by HPLC and UV method)

Supplier: ENZO LIFE SCIENCES
Description: Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

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Tyrphostin 1 95%

Supplier: Apollo Scientific
Description: Tyrphostin 1 95%

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Tyrphostin B7 ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

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Tyrphostin AG 1478 free base 99+%

Supplier: Apollo Scientific
Description: Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 uM). Eur. J. Biochem. 225: 1047-1053 (1994).

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Tyrphostin AG 183 ≥99%

Catalog Number: (ENZOBMLEI1890005)
Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.
UOM: 1 * 5 mg

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Tyrphostin AG 1295 ≥98%

Catalog Number: (ENZOALX270035M005)
Supplier: ENZO LIFE SCIENCES
Description: Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
UOM: 1 * 5 mg

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Tyrphostin AG 1478 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: EGFR inhibitor

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Tyrphostin AG-1296 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

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AG-879 ≥99%

Supplier: ENZO LIFE SCIENCES
Description: NGF receptor inhibitor

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Tyrphostin A25 ≥99%

Catalog Number: (ENZOBMLEI1870005)
Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).
UOM: 1 * 5 mg

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AG-494 ≥98% (by TLC)

Catalog Number: (ENZOBMLEI2280010)
Supplier: ENZO LIFE SCIENCES
Description: AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.
UOM: 1 * 10 mg

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Tyrphostin 1 ≥99%

Supplier: ENZO LIFE SCIENCES
Description: An inactive tyrphostin, which may be used as a negative control.

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