Tyrphostin AG 1478 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
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ALX270036M001 ALX270036M005
ENZOALX270036M001EA 55.1 GBP
ENZOALX270036M001 ENZOALX270036M005
Tyrphostin AG 1478 ≥98% (by HPLC)
Tyrphostin AG 1478

EGFR inhibitor


Potent and selective inhibitor of EGFR (IC50 = 3nM). Reduces EGF-stimulated DNA synthesis in Rat-1 fibroblasts by ~75% at 0.25μM. Blocks EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction in A431 cells. Also inhibits H2O2-induced stimulation of amphiregulin expression in rat gastric epithelium (RGM 1) cells.

Formula: C₁₆H₁₄ClN₃O₂
MDL Number: MFCD00270914
CAS Number: 153436-53-4

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