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Product Image-PRSI3997

Anti-TMED10 Rabbit Polyclonal Antibody

Catalog Number: (PRSI3997)
Supplier: ProSci Inc.
Description: TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
UOM: 1 * 100 µG
Product Image-PRSI4215

Anti-ORAI3 Rabbit Polyclonal Antibody

Catalog Number: (PRSI4215)
Supplier: ProSci Inc.
Description: ORAI3 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.
UOM: 1 * 100 µG
Product Image-0163-100G

Saponin, Reagent Grade

Catalog Number: (0163-100G)
Supplier: VWR Chemicals
Description: Saponin, Reagent Grade
UOM: 1 * 100 g

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Product Image-613-7308

VWR® Reagent Reservoirs

Supplier: VWR Collection
Description: Reagent reservoirs are designed for efficient liquid transfer, making them an ideal choice for repetitive pipetting tasks. These reagent reservoirs for multichannel pipettes provide a trough wide enough to fit 8 and 12 channel pipettes.

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Product Image-PRSI4211

Anti-CDKN2A Rabbit Polyclonal Antibody

Catalog Number: (PRSI4211)
Supplier: ProSci Inc.
Description: CDKN2A Antibody: The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.
UOM: 1 * 100 µG
Image Unavailable-73177-10X1G

Sanger's reagent ≥99.0% (by GC), LiChropur™ derivatisation reagent, for HPLC, Supelco®

Supplier: Merck
Description: Sanger's reagent ≥99.0% (by GC), LiChropur™ derivatisation reagent, for HPLC, Supelco®

Image Unavailable-1.09023.0500

GRIESS-ILOSVAY'S nitrite reagent for microbiology, Millipore®

Catalog Number: (1.09023.0500)
Supplier: Merck
Description: GRIESS-ILOSVAY'S nitrite reagent for microbiology, Millipore®
UOM: 1 * 500 mL

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Image Unavailable-11945-250ML

Benedict's reagent for qualitative detection of sugar in urine, Supelco®

Catalog Number: (11945-250ML)
Supplier: Merck
Description: Reagent used for the detection of reducing sugars and other reducing substances; detection limit: 0,01% glucose in water.
UOM: 1 * 250 mL
Product Image-PRSI4453

Anti-SLITRK1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI4453)
Supplier: ProSci Inc.
Description: Slitrk1 Antibody: SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.
UOM: 1 * 100 µG
Product Image-87875.180

Ninhydrin and stannous chloride reagent Reag. Ph. Eur. 1058301

Catalog Number: (87875.180)
Supplier: VWR Chemicals
Description: 2,2% ninhydrin with 0,09% tin II chloride in aqueous solution.
UOM: 1 * 100 mL

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Image Unavailable-M1942-100ML

Molybdenum Blue reagent, spray reagent, Sigma-Aldrich®

Catalog Number: (M1942-100ML)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: For use in the detection of phospholipids and related compounds.
UOM: 1 * 100 mL
Product Image-613-7309

VWR® 12-Channel Reagent Reservoirs

Supplier: VWR Collection
Description: These 12-channel reservoirs are made from high-quality, chemical resistant PP. Designed for serial dilutions or pipetting individual reagents using up to 12-channel pipetters.

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Product Image-613-7316

VWR® Reagent Reservoirs, PP

Supplier: VWR Collection
Description: These polypropylene multi-channel reagent reservoirs are designed to support both automated liquid handling platforms and manual systems. The reservoir design complies with ANSI/SLAS 1-2004, when used for cell culture and immunoassay experiments.

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Product Image-PRSI4117

Anti-ORAI3 Rabbit Polyclonal Antibody

Catalog Number: (PRSI4117)
Supplier: ProSci Inc.
Description: ORAI3 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.
UOM: 1 * 100 µG
Product Image-1.07913.0500

Reagents for Kjeldahl digestion

Supplier: Merck
Description: Boiling chips granules ~ 2 - 8 mm

SDS

Product Image-1.09011.0500

Nessler reagent A, Supelco®

Catalog Number: (1.09011.0500)
Supplier: Merck
Description: For determination of nitrogen Solution A : potassium tetraiodomercurate(II) solution
UOM: 1 * 500 mL

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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