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Image Unavailable-BOSSBS-6313R-BF647

Anti-4 HNE Rabbit Polyclonal Antibody (AbBy Fluor® 647)

Catalog Number: (BOSSBS-6313R-BF647)
Supplier: Bioss
Description: Aldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress 4-HNE has been hypothesised to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
UOM: 1 * 100 µl

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Image Unavailable-BOSSBS-15493R-FITC

Anti-IDO Rabbit Polyclonal Antibody (FITC)

Catalog Number: (BOSSBS-15493R-FITC)
Supplier: Bioss
Description: Catalyses the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2007R-CY7

Anti-PCNA Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-2007R-CY7)
Supplier: Bioss
Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11770R-A350

Anti-TMEM158 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-11770R-A350)
Supplier: Bioss
Description: Anti-TMEM158 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12201R

Anti-MELK Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-12201R)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12367R

Anti-TAZ Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-12367R)
Supplier: Bioss
Description: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1574R

Anti-RRM1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-1574R)
Supplier: Bioss
Description: Provides the precursors necessary for DNA synthesis. catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1409R

Anti-HSTF2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-1409R)
Supplier: Bioss
Description: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7511R

Anti-UTS2B Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-7511R)
Supplier: Bioss
Description: Potent vasoconstrictor.
UOM: 1 * 100 µl
Product Image-BOSSBS-1385R

Anti-ADAMTS12 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-1385R)
Supplier: Bioss
Description: Anti-ADAMTS12 Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Product Image-BOSSBS-0747R

Anti-RANKL Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0747R)
Supplier: Bioss
Description: Anti-RANKL Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Product Image-BOSSBS-1373R

Anti-NGAL/Lipocalin 2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-1373R)
Supplier: Bioss
Description: Anti-NGAL/Lipocalin 2 Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Product Image-BOSSBS-0780R

Anti-CXCL8 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0780R)
Supplier: Bioss
Description: Anti-CXCL8 Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Product Image-BOSSBS-9705R

Anti-ITM2A Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9705R)
Supplier: Bioss
Description: Anti-ITM2A Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Product Image-BOSSBS-0876R

Anti-AKT1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0876R)
Supplier: Bioss
Description: Anti-AKT1 Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0437R

Anti-Streptavidin Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0437R)
Supplier: Bioss
Description: Anti-Streptavidin Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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