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Image Unavailable-BOSSBS-12972R-FITC

Anti-PRKAA1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-12972R-FITC)
Supplier: Bioss
Description: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2771R-CY7

Anti-PRKAA2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-2771R-CY7)
Supplier: Bioss
Description: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12972R-A555

Anti-PRKAA1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-12972R-A555)
Supplier: Bioss
Description: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2771R-FITC

Anti-PRKAA2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-2771R-FITC)
Supplier: Bioss
Description: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM: 1 * 100 µl
Product Image-PRSI3499

Anti-RHEB Rabbit Polyclonal Antibody

Catalog Number: (PRSI3499)
Supplier: ProSci Inc.
Description: Rheb Antibody: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
UOM: 1 * 100 µG
Product Image-PRSI3501

Anti-RHEB Rabbit Polyclonal Antibody

Catalog Number: (PRSI3501)
Supplier: ProSci Inc.
Description: Rheb Antibody: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
UOM: 1 * 100 µG
Product Image-620-2693

Data logger for indoor air quality monitoring, Testo 160 IAQ

Catalog Number: (620-2693)
Supplier: Testo
Description: We spend a large part of our time indoors – in our homes, workplaces or public buildings. A bad indoor air quality can trigger certain health problems ; mold and fungi growth can cause allergies and asthma ; high CO₂ concentrations can cause headaches and concentration problems. Regular measurement of indoor air quality and comfort levels in workplaces enables the exact setting of the indoor climate and reduces the risk of staff shortages due to illness. Indoor air quality and comfort level measurement therefore also leads to fostering better staff performance.
UOM: 1 * 1 items
Product Image-PRSI55-210

Anti-GNAT3 Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-210)
Supplier: ProSci Inc.
Description: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
UOM: 1 * 400 µl
Product Image-MMMAX5001V-CE

Safety helmet, SecureFit™ X5000 series

Supplier: 3M
Description: 3M™ SecureFit™ Safety Helmet, X5000 series, provides secure, comfortable, and adjustable head protection for workers in a variety of situations. The helmets feature six different settings to adjust positions and 4-point chin strap selector systems to switch between EN 397 (industrial safety helmets) or EN 12492 (helmets for mountaineers) certification standards. X5000 series safety helmets are vented, brimless, and have 3M™ UVicator™ sensors that indicate levels of exposure to damaging ultraviolet (UV) light. The easily-adjustable, 6-point ratchet suspension system features the exclusive 3M™ pressure diffusion technology.

Product Image-SANYMCO-170-AC-PE

CO₂ incubators, MCO series, PHCbi

Supplier: PHC Corporation
Description: MCO incubators maintain a constant germicidal protection with inCu saFe™ a copper-enriched stainless steel interior chamber, HEPA filters and SafeCell™ UV (ultra-violet lamp, integrated in MCO-20AIC but optional for MCO-5AC). MCO-5AC and MCO-15AC utilise Thermal Conductivity (TC) sensors to monitor CO₂ levels whereas MCO-20AIC has unique ceramic-based IR Infrared sensors that deliver accurate CO₂ control with faster recovery after a door opening. Units with user-friendly design, accessories can be easily removed, reversible inner and outer doors, LED digital control and Ø 30 mm access port.

Product Image-181-0421

Fluid aspiration system, biochem vacuuCenter, BVC professional

Supplier: VACUUBRAND
Description: The VacuuCenter BVC professional serves for aspiration and disposal of biological fluids, providing outstanding levels of comfort and safety for working with biological and biohazardous materials. A non contact sensor monitors the liquid level in the collection bottle electronically and prevents overfilling. A disinfection routine allows the suction of disinfectants through an aspiration hand set and tubing after switching off the pump, and so supports demanding safety protocols. The BVC professional with 4 litre PP bottle that has self-closing quick couplings minimises risk in transporting hazardous waste and of contamination in the workplace. The version with coated 2 litre borosilicate glass bottle allows the user to work with aggressive disinfectants like chlorine bleach.

Product Image-BOHLR660-04

b.safe Isolated Amplifier 1-Channel

Catalog Number: (BOHLR660-04)
Supplier: Bohlender
Description: <p>Ready-to-install plastic housing made of ABS (IP66) protects against accidental contact with live contacts.</p>
UOM: 1 * 1 items

New Product


Product Image-HUBE2016.0014.04

Cooling and heating thermostats, stainless steel, with natural refrigerant, Ministats

Supplier: HUBER
Description: Their compact dimensions enable Ministats® to be placed in the smallest of spaces, for example in a laboratory fume cupboard or inside technical plant. Despite their minimal size the systems have a wide variety of features and offer performance levels suitable for temperature control of photometers, refractometers, viscometers, distillation apparatus, reaction vessels and mini-plants. They are mainly used for external applications, however the bath opening allows objects to be thermoregulated directly in a thermostat bath. A powerful pressure/suction pump with an infinitely controlled rotational speed ensures optimum circulation. The maximum pressure can also be regulated by an optional pressure sensor, meaning that sensitive glass reactors and apparatus can be protected from breakage. Ministats® have the 'professional' level Pilot ONE<B>®</B> controller as standard with a colour TFT display and convenient operator guidance. Analogue NAMUR connections are available via the optional Com.G@te module allowing Ministats® to be integrated into plant and process control systems. The Pilot ONE® multi-touch controller features a brilliant 14,5 cm touchscreen with graphic functions and easy navigation menu in 11 languages. All important operating parameters and temperature values are clearly displayed on the touchscreen. The favourites menu, one-click operation and the integral technical glossary mean operation is simple. Integrated USB and Ethernet ports allows connection to a PC or network, e.g. for remote control or data transmission.

Product Image-441-0391

Electronic overhead stirrers, Hei-TORQUE series

Supplier: Heidolph Instruments GmbH & Co.KG
Description: Powerful electronic stirrers that feature a smooth start operation which prevents spills and splashing media. The speed ramps up slowly until set speed has been reached. Both models feature safe start and stop of operation via an intuitive glass slide touch panel to avoid accidental start-up. An overtemperature sensor shuts off the unit in dangerous heat-up situations, ideal for unattended continuous operation. All units are designed for continuous 24-hour operation, including challenging high viscosity applications in polymer research. High torque levels give better mixing results in less time, maintenance-free motors reduce repairs and down time. Hei-TORQUE Value 400 and Hei-TORQUE Precision 400 units have two speed gears.

Product Image-MFLX19406-48

PendoTECH® Single-Use Pressure Sensor Accessories

Supplier: Avantor Fluid Handling
Description: Optimize performance of your PendoTECH® Pressure Sensor.

CE Compliant

Product Image-MFLX24500-19

LEVIFLOW® Single-Use Clamp-On Ultrasonic Flow Sensors

Supplier: Avantor Fluid Handling
Description: No moving parts—no particle generation—no contamination.

CE Compliant

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
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Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
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The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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