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Image Unavailable-BOSSBS-13328R-A488

Anti-GEMIN4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-13328R-A488)
Supplier: Bioss
Description: Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13328R-A350

Anti-GEMIN4 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-13328R-A350)
Supplier: Bioss
Description: Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
UOM: 1 * 100 µl
Product Image-390-0851

CO₂ incubators, MCO-170AIC/19M series, PHCbi

Catalog Number: (390-0851)
Supplier: PHC Corporation
Description: These units are designed for demanding and regulated applications in the biomedical, pharmaceutical, medical research and clinical laboratory. They offer outstanding performance and advanced, multi-level contamination control to provide the ideal solution for cell culture protocols. The patented SafeCell™ UV treats interior airflow to destroy airborne and humidity pan contaminants and inCu saFe copper-enriched stainless steel interior surfaces assure constant germicidal protection. When total chamber decontamination with verification is required, the unique H₂O₂ decontamination option limits downtime to less than three hours.
UOM: 1 * 1 items
Product Image-710-1780

DNA extraction and purification kit

Supplier: Q BIOANALYTIC
Description: Successful PCR applications depend on well purified DNA. In diagnostics and analytics of food and medical samples PCR and real-time PCR has many advantages over conventional methods. In all cases it is of importance to have well purified DNA for subsequent PCR, real-time PCR, hybridization or sequencing purposes. Purified DNA leads to higher sensitivity and also specificity of PCR based tests in difficult matrices. With QuickBlue Extraction and Purification Kit you always get high DNA yields and highly purified DNA. The kit uses paramagnetic nano-particles for purification. It can help to purify DNA from difficult matrices like food or even blood in soil for applications in forensic sciences. DNA in Seawater can also be purified. This method avoids extensive centrifugation steps and can thus be applied in environments where centrifuges are not usable. The kits includes proteinase K as a reagent for cell disruption, so that extraction and purification can be performed with the kit. DNA yield from 1 ml bacterial enrichment is 10 μg of Genomic DNA. The protocol can be adapted to automated magnetic bead separation instruments.

Product Image-PRSI96-302

Human recombinant CD95 (from HEK293 cells)

Catalog Number: (PRSI96-302)
Supplier: ProSci Inc.
Description: The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.
UOM: 1 * 100 µG
Image Unavailable-FRIT22.9040.00

Laser Particle Sizer, ANALYSETTE 22 NeXT Nano

Catalog Number: (FRIT22.9040.00)
Supplier: FRITSCH
Description: ANALYSETTE 22 NeXT Nano comes with an extra wide measuring range of 0,01 to 3800 μm for maximum precision and sensitivity for smallest particles with an additional detector system.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-11882R

Anti-MAGOH Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-11882R)
Supplier: Bioss
Description: MAGOH, the human homolog of Drosophila mago nashi, is required for embryo development. MAGOH is ubiquitously expressed in adult tissues. It has an unusual structure consiting of an extremely flat, six-stranded anti-parallel β sheet packed next to two helices. MAGOH interacts with the Y14 protein to form a complex that plays a crucial role in postsplicing processing (including nuclear export and cytoplasmic localization of the mRNA) and in the nonsense-mediated mRNA decay (NMD) surveillance process. The MAGOH-Y14 complex remains persistently associated in the same position on the mRNA after its export to the cytoplasm and requires translation of the mRNA for removal. This complex may illustrate the mechanism of the pre-mRNA splicing machinery for forming a stable exon-exon junction complex-mRNA at splice junctions.
UOM: 1 * 100 µl
Product Image-733-2897

UDI adapters (1-96), sparQ

Catalog Number: (733-2897)
Supplier: Quantabio
Description: sparQ UDI Adapters (1-96) are unique dual-indexed adapters designed to be used on illumina sequencing platforms. It is compatible with both DNA and RNA libraries. The use of UDI’s minimises index hopping events while also enabling greater multiplexing on flow cells.
UOM: 1 * 1 KIT
Product Image-ELET03076-28

Cole-Parmer® HM-200 Multi-Position Extraction Heaters

Supplier: Cole-Parmer
Description: Allow liquids with different boiling points to be heated next to each other.

Product Image-HEWLG1361-67302

Capillaries for LC systems

Catalog Number: (HEWLG1361-67302)
Supplier: Agilent
Description: Stainless steel capillaries are made of flexible stainless steel (0,6 mm OD) with ¹/₁₆" OD tubing at both ends to accept standard fittings.
UOM: 1 * 1 items
Product Image-ELET03076-22

Cole-Parmer® SHM-200 Multiposition Extraction Heater/Stirrers

Supplier: Cole-Parmer
Description: Allows liquids with different boiling points to be heated and or stirred next to each other.

Image Unavailable-BOSSBS-13328R-A680

Anti-Gemin 4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-13328R-A680)
Supplier: Bioss
Description: Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13328R-A647

Anti-GEMIN4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-13328R-A647)
Supplier: Bioss
Description: Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
UOM: 1 * 100 µl
Product Image-662-2745

Accessories for Mettler FiveEasy™ / FiveGo™ / SevenGo™ / SevenMulti™ meters

Catalog Number: (662-2745)
Supplier: Mettler - Toledo
Description: SevenGo™ clip (electrode holder that can be placed next to the display on either side of the housing), For: Mettler SevenGo™
UOM: 1 * 1 items
Product Image-PRSI55-647

Anti-PIP Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-647)
Supplier: ProSci Inc.
Description: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
UOM: 1 * 400 µl

New Product


Image Unavailable-71003-3

DNA polymerases

Supplier: Merck Millipore (Novagen)
Description: KOD HiFi DNA Polymerase is a unique proofreading enzyme, isolated from the extreme thermophile <i>Thermococcus kodakaraensis</i> KOD1, which possesses superior processivity and fidelity that enables faster and more accurate PCR amplification than can be achieved with conventional enzymes.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
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The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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