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Image Unavailable-BOSSBS-11332R

Anti-CNG channel beta 1/truncated GARP Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-11332R)
Supplier: Bioss
Description: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11332R-CY3

Anti-CNG channel beta 1/truncated GARP Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-11332R-CY3)
Supplier: Bioss
Description: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
UOM: 1 * 100 µl
Product Image-AATB22839

Cell Meter™ FITC-Annexin V Binding Apoptosis Assay Kit *Optimized for Flow Cytometry*

Catalog Number: (AATB22839)
Supplier: AAT BIOQUEST
Description: Our Cell Meter™ FITC-Annexin V binding assay kit is designed to monitor cell apoptosis through measuring the translocation of phosphatidylserine (PS).
UOM: 1 * 100 Tests
Product Image-C-14095

Human pericytes from placenta (hPC-PL)

Supplier: PROMOCELL
Description: Pericytes are multipotent mesenchymal-like cells found in association with small blood vessel walls and are important for angiogenesis, the structural integrity of the microvasculature and blood flow regulation. However, they can also develop into malignant tumours called hemangiopericytomas.

Product Image-HEWLG1321-60005

Supplies for fluorescence detector (FLD), G1321A/B 1100/1200 series

Catalog Number: (HEWLG1321-60005)
Supplier: Agilent
Description: Flow cell, 8 μl, 20 bar, For: G 1321A/B 1100/1200
UOM: 1 * 1 items
Product Image-AATB16351

Cell Meter™ Fluorimetric Intracellular Nitric Oxide (NO) Activity Assay Kit *Orange Fluorescence Optimized for Flow Cytometry*

Catalog Number: (AATB16351)
Supplier: AAT BIOQUEST
Description: Nitric oxide (NO) is an important biological regulator involved in numbers of physiological and pathological processes.
UOM: 1 * 100 Tests
Product Image-AATB16317

Cell Meter™ Fluorimetric Intracellular Peroxynitrite Assay Kit *Optimized for Flow Cytometry*

Catalog Number: (AATB16317)
Supplier: AAT BIOQUEST
Description: Peroxynitrite (ONOO-) is a strong oxidizing species and a highly active nitrating agent.
UOM: 1 * 100 Tests
Image Unavailable-BOSSBS-11332R-A350

Anti-CNG channel beta 1/truncated GARP Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-11332R-A350)
Supplier: Bioss
Description: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
UOM: 1 * 100 µl
Product Image-432-0267

Probes and accessories for Vibra-Cell™ ultrasonic processors

Supplier: SONICS MATERIALS
Description: A wide range of probes for a variety of applications is available, including stepped and tapered microtips and also probes for processing in microplates.

Product Image-AATB16356

Cell Meter™ Fluorimetric Intracellular Nitric Oxide (NO) Activity Assay Kit *Red Fluorescence Optimised for Flow Cytometry*

Catalog Number: (AATB16356)
Supplier: AAT BIOQUEST
Description: Nitric oxide (NO) is an important biological regulator involved in numbers of physiological and pathological processes.
UOM: 1 * 100 Tests
Product Image-734-5950

Cell strainers for 1000 µl pipette tips, Flowmi™, SP Bel-Art

Supplier: Bel-Art Products, a Part of SP
Description: Scienceware® Flowmi™ cell strainers provide fast and efficient filtering of small volume samples (up to 1000 µl) prior to FLOW or FACS analysis. Patent pending.

Product Image-662-0766

Reference electrode, half cell, Orion™ 900200 Sure-Flow™

Catalog Number: (662-0766)
Supplier: Thermo Orion
Description: This electrode is a sleeve-type refillable Ag/AgCl (silver/silver chloride) reference electrode with an outer chamber that isolates the inner reference element and filling solution from the sample. This electrode is designed for precision measurements with ion selective half-cell electrodes and pH half-cell electrodes.
UOM: 1 * 1 items

Certificates


Product Image-AATB22258

CytoTell™ Orange

Supplier: AAT BIOQUEST
Description: Flow cytometry combined with fluorescence staining is a powerful tool to analyse heterogeneous cell populations.

Image Unavailable-BOSSBS-9847R-A750

Anti-AE2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-9847R-A750)
Supplier: Bioss
Description: Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis.
UOM: 1 * 100 µl
Product Image-AATB22251

CytoTell™ Blue

Supplier: AAT BIOQUEST
Description: Flow cytometry combined with fluorescence staining is a powerful tool to analyse heterogeneous cell populations.

Image Unavailable-BOSSBS-9847R-A680

Anti-AE2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-9847R-A680)
Supplier: Bioss
Description: Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
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Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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