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Image Unavailable-BOSSBS-13026R-CY3

Anti-DNMT3L Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-13026R-CY3)
Supplier: Bioss
Description: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5190R-A350

Anti-ATF4 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-5190R-A350)
Supplier: Bioss
Description: ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5190R-A555

Anti-ATF4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-5190R-A555)
Supplier: Bioss
Description: ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9603R-FITC

Anti-TEF3 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-9603R-FITC)
Supplier: Bioss
Description: TEF-3, is a 427 amino acid member of the transcriptional enhancer factor (TEF) family of proteins that are characterized by the presence of a TEA DNA-binding domain. Localized to the nucleus and expressed primarily in skeletal muscle, TEF-3 functions as a transcriptional regulator by binding specifically and non-cooperatively to the M-CAT motif found in the promotors of muscle-specific genes, thereby directing their subsequent expression. TEF-3 contains one TEA DNA-binding domain and is expressed as multiple isoforms due to alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15486R-A647

Anti-HIC2 Rabbit Polyclonal Antibody (ALEXA FLUOR® 647)

Catalog Number: (BOSSBS-15486R-A647)
Supplier: Bioss
Description: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15486R

Anti-HIC2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-15486R)
Supplier: Bioss
Description: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
UOM: 1 * 100 µl
Product Image-735-0273

Nucleic acid and protein purification systems, KingFisher™

Catalog Number: (735-0273)
Supplier: Thermo Fisher Scientific
Description: The KingFisher™ magnetic particle processors are designed to automate time consuming sample processing of nucleic acids, proteins or cells from virtually any source (blood, cell cultures, tissue lysates, soil, faeces, for example). The KingFisher™ family consists of instruments with different throughput and volume capacities to fulfil individual sample processing needs. Each system consists of an instrument, specially designed plastics, and software. The KingFisher™ systems offer rapid and reproducible purification of high quality DNA, RNA, proteins and cells for various types of downstream applications, including genomics and proteomics, drug discovery, forensics, biomarker discovery, quality control, and veterinary assays.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-9603R-A680

Anti-TEF3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-9603R-A680)
Supplier: Bioss
Description: TEF-3, is a 427 amino acid member of the transcriptional enhancer factor (TEF) family of proteins that are characterised by the presence of a TEA DNA-binding domain. localised to the nucleus and expressed primarily in skeletal muscle, TEF-3 functions as a transcriptional regulator by binding specifically and non-cooperatively to the M-CAT motif found in the promotors of muscle-specific genes, thereby directing their subsequent expression. TEF-3 contains one TEA DNA-binding domain and is expressed as multiple isoforms due to alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5306R-FITC

Anti-E2F1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-5306R-FITC)
Supplier: Bioss
Description: E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5305R-FITC

Anti-E2F1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-5305R-FITC)
Supplier: Bioss
Description: E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5305R-A350

Anti-E2F1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-5305R-A350)
Supplier: Bioss
Description: E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5305R-A555

Anti-E2F1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-5305R-A555)
Supplier: Bioss
Description: E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9491R-A750

Anti-SOSSC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-9491R-A750)
Supplier: Bioss
Description: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent Signalling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-ROCKMB-045

SSC buffer, 20X concentrate, pH 7,0

Catalog Number: (ROCKMB-045)
Supplier: Rockland Immunochemicals
Description: Saline-sodium citrate (SSC) buffer is most commonly used as a buffer for the hybridisation process and washing in experiments where spcies of nucleic or ribonucleic acid are to be matched to complimentary sequences (such as Southern and Nouthern blotting, <i>in situ</i> hybridisation, or DNA microarrays). SSC is used to help control the stringency of hybridisation in these steps.
UOM: 1 * 1 L
Image Unavailable-BOSSBS-12212R-A555

Anti-ZNF342 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-12212R-A555)
Supplier: Bioss
Description: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Krüppel C2H2-type zinc-finger protein family, ZNF342 (zinc finger protein 342), also known as Zinc finger protein 296, is a 475 amino acid nuclear protein that contains six C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12908R-A750

Anti-ZNF851/BTBD15/ZBTB44 Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Catalog Number: (BOSSBS-12908R-A750)
Supplier: Bioss
Description: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying protein. ZBTB44 is a 570 amino acid member of the Kr_ppel C2H2-type Zinc-finger protein family. Localised to the nucleus, ZBTB44 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerisation. Characteristics of the BTB domain suggest that ZBTB44 functions as a transcription regulator. Four isoforms of ZBTB44 have been identified.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
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