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Rotary vane vacuum pumps

Supplier: LABCONCO
Description: This vacuum pump is designed for use with aqueous samples that are compatible with FreeZone Freeze Dry Systems, CentriVap Centrifugal concentrators and Protector® Controlled Atmosphere glove boxes. It comes with a single phase direct drive motor, totally enclosed and fan cooled. When the motor overheats, the thermal overload device switches off the pump. When the pump cools down, the motor automatically restarts. Isolation valve seals the inlet to prevent oil and air contamination of the system in the event of power failure.

Image Unavailable-BOSSBS-4897R-A647

Anti-ACKR3 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-4897R-A647)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl

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uvex silv-Air e Particulate Respirator, FPP2/FPP3

Supplier: UVEX
Description: All masks of the uvex silv-Air e family combine our unique technologies of optimum wearer comfort with extremely low breathing resistance. The products are therefore suitable for heavy work and for being worn for long periods of time. The increased size of the filter surface even enables the high-performance models to be worn for several days.

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Image Unavailable-BOSSBS-9474R-HRP

Anti-NFAT5 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-9474R-HRP)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9474R-A750

Anti-NFAT5 Ser1197 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-9474R-A750)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localised to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localisation signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9474R-CY3

Anti-NFAT5 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-9474R-CY3)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15371R-HRP

Anti-GPCR RDC1 Rabbit Polyclonal Antibody (HRP)

Catalog Number: (BOSSBS-15371R-HRP)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Image Unavailable-ILMV700562

Manual Vacuum Regulation Turret, Flush Mount

Catalog Number: (ILMV700562)
Supplier: Welch by Gardner Denver
Description: Open/close the vacuum line and easily control flow rate.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-9474R-A488

Anti-NFAT5 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-9474R-A488)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Product Image-REST20647

Single stage ultra high purity chrome plated brass gas regulators

Supplier: Restek
Description: These chrome plated brass body ultra high purity gas regulators are ideal for sensitive GC applications using MS, PID and ECD detection methods. It features reduced internal dead volume relative to stainless steel bodies.

Product Image-REST20663

Dual stage gas regulators

Supplier: Restek
Description: These regulators are the standard for ultra high purity and corrosion resistant pressure regulation. They are more easily purged of atmospheric components compared to brass gas regulators. Stainless steel is especially useful in atmospheres of dry corrosive gases such as hydrogen.

Product Image-REST21667

Dual stage ultra high purity gas regulators

Supplier: Restek
Description: Ultra high purity gas regulators are ideal for sensitive GC applications using MS, PID and ECD detection methods. They feature reduced internal dead volume relative to stainless steel bodies.

Image Unavailable-JOURJR-BPR2

Back pressure regulator

Supplier: VICI JOUR RESEARCH
Description: This regulator installs on the detector drain line and prevents bubble formation in the flow cell during outgassing. It has an adjustable back pressure from 0 to 20 bar (15 to 300 psi) without disconnecting from the system. Other sizes available.

Image Unavailable-BOSSBS-4897R-A555

Anti-ACKR3 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-4897R-A555)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Product Image-REST20668350

Automatic switchover system for noncorrosive gases, with line regulator

Supplier: Restek
Description: These high-purity automatic switchover systems provide a continuous supply of high-purity gas to the laboratory, process or instrument to a depleted gas source without interruption in the gas supply.

Image Unavailable-HEWL19246-60560

Back pressure regulator

Catalog Number: (HEWL19246-60560)
Supplier: Agilent
Description: Back pressure regulator, 1 - 15 psi
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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