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Image Unavailable-BOSSBS-4897R-A680

Anti-CXCR7/RDC1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-4897R-A680)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15371R-A488

Anti-GPCR RDC1 Rabbit Polyclonal Antibody (ALEXA FLUOR® 488)

Catalog Number: (BOSSBS-15371R-A488)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl

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Image Unavailable-BOSSBS-15371R-A680

Anti-GPCR RDC1 Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)

Catalog Number: (BOSSBS-15371R-A680)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Product Image-UPCHU-610

Back pressure regulators, Upchurch Scientific®

Supplier: UPCHURCH SCIENTIFIC
Description: Back pressure regulator assemblies are designed to create incremental back pressures ranging from 5 to 1000 psi (0,3 to 69 bar). These biocompatible and stainless steel back pressure regulator assemblies are available complete with a replaceable, factory pre-set cartridge (except the 5 and 20 psi (0,3 to 1,4 bar versions).

Product Image-181-0259

Accessories for diaphragm pump

Supplier: VACUUBRAND
Description: Vacuum diaphragm pump, Vacuum regulator valve unit for ME 1

Product Image-ILMV829909

Accessories for dry vacuum and chemically resistant diaphragm pumps, ILMVAC

Supplier: Welch by Gardner Denver
Description: Vacuum diaphragm pump, Vacuum regulator with digital gauge and pressure release valve, for MP/MPC/ 095 Z, 110 E, MPC 105 T, MPC 155 Z

Product Image-HECH41390001

Bunsen burners

Catalog Number: (HECH41390001)
Supplier: GLASWARENFABRIK KARL HECHT
Description: Bunsen burners with air regulation. Head ~ Ø15 mm.
UOM: 1 * 1 items
Product Image-554-3073

Ultra-low volume back pressure regulators (BPR), Upchurch Scientific®

Supplier: UPCHURCH SCIENTIFIC
Description: These ultra-low volume back pressure regulators (BPRs) are developed to minimise swept volume, which is especially important for multi-detector applications.

Image Unavailable-COLE02017-09

Idex® Back Pressure Regulator (BPR) Holder

Catalog Number: (COLE02017-09)
Supplier: Cole-Parmer
Description: Enhance system performance through outgassing prevention.
UOM: 1 * 1 items

New Product


Product Image-BOCH7100

Burners, Teclu

Supplier: BOCHEM
Description: These burners have air regulation and reach a maximum temperature of 1300 °C.

Product Image-BSBTPB9980

Anti-AIRE Rabbit Polyclonal Antibody

Catalog Number: (BSBTPB9980)
Supplier: Boster Bio
Description: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
UOM: 1 * 100 µG
Product Image-HEWL5183-4645

Gas cylinder supplies

Supplier: Agilent
Description: A broad spectrum of economical brass regulators, wall brackets, and NPT adapters.

Product Image-REST21347

Protocol wall mounts for gas regulators

Supplier: Restek
Description: The protocol station is designed for convenient wall mounting of high-purity gas regulators.

Product Image-PRSI27-660

Anti-AIRE Rabbit Polyclonal Antibody

Catalog Number: (PRSI27-660)
Supplier: ProSci Inc.
Description: AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
UOM: 1 * 100 µG
Product Image-181-0332

Vacuum controller, CVC 3000, benchtop

Catalog Number: (181-0332)
Supplier: VACUUBRAND
Description: The CVC 3000 detect compact vacuum controller complete with integral vacuum valve and sensor is ready to use either as a bench top or stand mounted unit. The CVC 3000 detect is a compact two-point vacuum regulator, with integrated ceramic vacuum sensor and ventilation valve. The "detect" function provides the ability to recognise and find the boiling pressure and thus greatly facilitates the work of solvent evaporation. With integrated non-return valve and chemistry vacuum valve, it forms a highly compact and easy-to-install unit for vacuum regulation. Used in conjunction with existing vacuum pumps or networks, process efficiency is significantly increased through the "detect" electronic vacuum control, the solvent recovery is increased and the environment better protected. The programmable CVC 3000 detect is available for both bench top and stand mounting operation.
UOM: 1 * 1 items

Environmentally Preferable


Product Image-BOCH7430

Teclu burners, all gases

Catalog Number: (BOCH7430)
Supplier: BOCHEM
Description: Multi gas burner with stopcock works to a maximum of 1300 °C.
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on 0800 22 33 44
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
Additional Documentation may be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalogue Number listed above. If you need further assistance, please call VWR Customer Service on 0800 22 33 44.
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