Aluminon ACS, Sigma-Aldrich®

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Synonyms: Ammonium 5,5'-((3-carboxylato-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoate)Aurin Tricarboxylic Acid Ammonium Salt

M-Clarity™ quality level = MQ300

A36883-25GEA 64.5 GBP
A36883-25G A36883-100G
Aluminon ACS, Sigma-Aldrich®
Aluminon

Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.

Formula: C₂₂H₂₃N₃O₉
MW: 473.44 g/mol
Melting Pt: 220...225 °C (dec., lit.)
Storage Temperature: Room Temperature
MDL Number: MFCD00040925
CAS Number: 569-58-4
EINECS: 209-319-1

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Specification Test Results

Appearance (Colour) Red to Very Dark Red and Red-Brown and Brown-Red
Appearance (Form) Powder or Crystals
Infrared spectrum Conforms to Structure
Insoluble matter, c = 1%, Water and Dilute NH4OH ≤0.1%
Sensitivity Test, Sensitivty to Aluminum Pass
Residue on ignition (Ash) ≤0.2%
Solubility (Colour) c = 100 mg/ml; Water Red to Very Dark Red and Red-Brown and Brown-Red

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