Salicylic acid 99.5-105.0% (by acidimetry on anhydrous substance), EMPROVE® ESSENTIAL Ph. Eur., BP, USP, SAFC®
Supplier: MERCK PRODUCTION CHEMICALS
Ratings:
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Total Ratings: 0
Avg. Ratings: 0.0 out of 5
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Danger
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Synonyms:
o-Hydroxybenzoic acid
, 2-Hydroxybenzoic acid
1.00631.9024EA
816
GBP
1.00631.9024
1.00631.1000
Salicylic acid 99.5-105.0% (by acidimetry on anhydrous substance), EMPROVE® ESSENTIAL Ph. Eur., BP, USP, SAFC®
Salicylic acid
Formula:
(HO)C₆H₄CO₂H MW: 138.12 g/mol Boiling Pt: 336 °C (1013 hPa) Melting Pt: 157…159 °C Density: 1.443 g/cm³ (20 °C) Flash Pt: 157 °C Storage Temperature: Ambient |
MDL Number:
MFCD00002439 CAS Number: 69-72-7 EINECS: 200-712-3 Merck Index: 13,08411 |
Specification Test Results
Assay (acidimetric; calculated on dried substance) | 99.5 - 100.5 % |
Assay (HPLC, calc.on dried substance) | 98.0 - 102.0 % |
Identity | passes test |
Appearance of solution (10 %; ethanol 96 %) | passes test |
Chloride (Cl) | ≤ 0.0100 % |
Sulfate (SO₄) | ≤ 0.0200 % |
Related substances / HPLC (EP) (4-Hydroxybenzoic acid) | ≤ 0.1 % |
Related substances / HPLC (EP) (4-Hydroxyisophthalic acid) | ≤ 0.05 % |
Related substances / HPLC (EP) (Phenol) | ≤ 0.02 % |
Related substances / HPLC (EP) (Largest unspecified impurity) | ≤ 0.05 % |
Related substances / HPLC (EP) (Sum of all impurities) | ≤ 0.2 % |
Related substances / HPLC (USP) (4-Hydroxybenzoic acid) | ≤ 0.1 % |
Related substances / HPLC (USP) (4-Hydroxyisophthalic acid) | ≤ 0.05 % |
Related substances / HPLC (USP) (Phenol) | ≤ 0.02 % |
Related substances / HPLC (USP) (Largest unspecified impurity) | ≤ 0.05 % |
Related substances / HPLC (USP) (Sum of all impurities) | ≤ 0.2 % |
Residual solvents (ICH Q3C) | excluded by manufacturing process |
Sulfated ash | ≤ 0.05 % |
Loss on drying | ≤ 0.5 % |
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*). | |
corresponds to Ph Eur, BP, USP |
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