1,4-Dithioerythritol ≥99%, white crystalline powder

Supplier: MP Biomedicals
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Synonyms: Cleland's ReagentDL-Dithioerythritoltrans-1,4-Dimercaptobutane-2,3-diolDTEDithioerythritol(R*,S*)-1,4-Dimercaptobutane-2,3-diolErythro-1,4-Dimercaptobutane-2,3-diol

ICNA0210059810EA 254 GBP
ICNA0210059810 ICNA0210059801 ICNA0210059825 ICNA0210059805 ICNA02100598.5 ICNA0210059880
1,4-Dithioerythritol ≥99%, white crystalline powder
1,4-Dithioerythritol

Dithioerythritol is an erythro isomer of 2,3-dihydroxy-1,4-dithiolbutane, and an isomer of 1,4-dithiothreitol which is a reagent for maintaining thiols in the reduced state; prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. It also quantitatively reduces disulfides.


Dithioerythritol is used to prepare a matrix for fast-atom bombardment mass spectroscopy. It has been reported to be used in 2-D electrophoretic analysis of proteins and immunoglobulins, mitochondrial studies to block the opening of the transition pore and to study permeability transition, glial and neuronal glycine transporters have been investigated, utilised in a mass spectrometric mapping study of disulphide bonds in recombinant human interleukin-13.


Soluble in water (50 mg/ml - clear to slightly hazy, colourless solution).


Caution: Store at +4 °C, protect from light, store under nitrogen

Formula: C₄H₁₀O₂S₂
MW: 154.25 g/mol
Melting Pt: 82 - 83 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00063750
CAS Number: 6892-68-8
EINECS: 229-998-8
UN: 3335
ADR: 3,III

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Specification Test Results

Identity Test Passes
Purity ≥99%
FTIR Conforms to Reference
Melting Point 80 - 90 °C
UV/ VIS: OD283 (0,02 M aq soln) ≤0,04

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