Anti-CD34 Mouse Monoclonal Antibody [clone: 8G12] (APC)

Supplier: STEMCELL Technologies
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STMC60121AZEA 1077 GBP
STMC60121AZ
Anti-CD34 Mouse Monoclonal Antibody [clone: 8G12] (APC)
Antibodies
Mouse monoclonal IgG1 antibody against human CD34, APC-conjugated.

  • Hematopoietic stem
  • Progenitor cells

CD34 is an ~105 to 120 kDa type 1 transmembrane glycoprotein expressed on the surface of most human hematopoietic stem and progenitor cells (HSPCs), as well as on endothelial cells and some tumor cell lines. The frequency of CD34+ cells is low in bone marrow (1 to 4%), cord blood (~1%), and peripheral blood (<0,1%). CD34 is used to identify and isolate HSPCs, including those capable of reconstituting hematopoiesis after transplantation. Distinct epitope groups have been assigned to CD34 based on differences in the structure of carbohydrate groups, which affects their sensitivity to enzymatic cleavage. The 8G12 antibody recognizes a class III epitope (resistant to neuraminidase and O-glycoprotease). Clone 8G12 does not recognize rhesus macaque CD34.

Type:
Antigen: CD34
Clonality: Monoclonal
Clone: 8G12
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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