Polymyxin B sulphate, ≥6000 USP units/mg, powder, BioReagent cell culture reagent, Sigma-Aldrich®

Supplier: Merck
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M-Clarity™ quality level = MQ200

P4932-1MU P4932-5MU
SIALP4932-1MUEA 61.6 GBP
SIALP4932-1MU SIALP4932-5MU
Polymyxin B sulphate, ≥6000 USP units/mg, powder, BioReagent cell culture reagent, Sigma-Aldrich®
Polymyxin B sulphate

Polymyxin B sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.


Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilised agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.


Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections


Polymyxin B sulfate is soluble in water at 50 mg/ml, producing a very slightly hazy, colourless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0,115 mg/ml in ethanol. This product is biotechnology performance certified.


As supplied, the product should be stored at 2 to 8°C in the dark. No change was observed in retained samples after three years storage in these conditions. Stock solutions should be sterile filtered and stored at 2 to 8 °C. They are stable at 37 °C for 5 days.

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄
MDL Number: MFCD00131991
CAS Number: 1405-20-5

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