Thiolutin Streptomyces luteosporeus 95 HPLC, TLC

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Synonyms: 6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]-pyrrol-5(4H)-one

BMLCT1070001 BMLCT1070005
ENZOBMLCT1070001EA 166 GBP
ENZOBMLCT1070001 ENZOBMLCT1070005
Thiolutin Streptomyces luteosporeus 95 HPLC, TLC
Thiolutin

Sulfur containing antibiotic. Potent inhibitor of bacterial and yeast RNA polymerases. Inhibits mRNA chain elongation. Inhibits adhesion of endothelial cells (HUVECs) to vitronectin (IC50=0.83 µM) thereby inhibiting tumor cell-induced angiogenesis in vivo. Inhibits transcription in C. albicans. Inhibits microbiological growth in beer. Active against soil borne pathogens.


  • RNA polymerase inhibitor


Yellow crystalline solid.


Soluble in DMSO (5mg/ml), very slightly soluble in water

Formula: C₈H₈N₂O₂S₂
MW: 228.3 g/mol
Storage Temperature: Freezer
CAS Number: 87-11-6
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