Geldanamycin ≥95% (by HPLC)
Supplier: ENZO LIFE SCIENCES AGTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
Potent antitumor antibiotic. Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes.
- Yellow solid
Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against alpha-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes. 10-fold more potent than herbimycin A.
Soluble in DMSO (10 mg/mL); insoluble in water
Packaging: Shipping temperature: Ambient
Formula:
C₂₉H₄₀N₂O₉ MW: 560.64 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00274570 CAS Number: 30562-34-6 |
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