Human recombinant Amphiregulin (from E. coli)
Supplier: Shenandoah BiotechnologyTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.
- Animal-free
- Produced from genetically modified E. coli
- Monomeric protein, containing 87 amino acids
- Promotes ductal outgrowth and mammary branching
- Up-regulated at puberty
- Functions as a mitogen and prevents hepatocyte apoptosis in liver
AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). In a cancer, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia. It also promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium.
Delivery information: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
Caution: This product is for research use only and is not for use in humans.
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