Cystamine dihydrochloride ≥95%, crystalline solid

Supplier: Cayman Chemical
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Synonyms: Cystaminium dichloride, 2,2′-Diaminodiethyl disulphide dihydrochloride, 2,2'-Disulphanediyldiethanamine dihydrochloride, Bis(2-aminoethyl) disulphide dihydrochloride, Decarboxycystine dihydrochloride, Cystamine (dihydrochloride), {2-[(2-Aminoethyl)disulphanyl]ethyl}amine dihydrochloride, 2,2′-Dithiobis(ethylamine) dihydrochloride

14882-100 14882-25 14882-50 14882-500
CAYM14882-100EA 202 GBP
CAYM14882-100 CAYM14882-25 CAYM14882-50 CAYM14882-500
Cystamine dihydrochloride ≥95%, crystalline solid
Cystamine dihydrochloride

Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.


It is orally available and is neuroprotective in mouse models of Huntington’s disease. Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.


Tissue transglutaminase (TGM2) post-translationally modifies proteins by catalyzing intermolecular cross-linkages between glutamine and lysine side chains. TGM2 has roles in neurodegenerative disorders, celiac sprue, cancer, and fibrotic diseases.

Formula: C₄H₁₂N₂S₂·2HCl
MW: 225.20 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00012905
CAS Number: 56-17-7

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