Poly(ethylene glycol)diglycidyl ether, M.W. 500 (Mn), liquid, Sigma-Aldrich®

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M-Clarity™ quality level = MQ200

475696-500ML 475696-100ML
SIAL475696-500MLEA 193 GBP
SIAL475696-500ML SIAL475696-100ML
Poly(ethylene glycol)diglycidyl ether, M.W. 500 (Mn), liquid, Sigma-Aldrich®
Poly(ethylene glycol)diglycidyl ether

The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxide.


  • Glycidyl - α and Ω end groups
  • Linear, homobifunctional polymer architecture
  • Cross-linking reagent for amine reactive groups


It easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries as cross linkers and surface modifier.

Formula: C₃H₅O₂-(C₂H₄O)n-C₃H₅O
Density: 1.14 g/ml (25 °C) (lit.)
Flash Pt: 197 °C
MDL Number: MFCD00130930
CAS Number: 72207-80-8

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Specification Test Results

Appearance (Color) Colorless
Appearance (Form) Liquid
Proton NMR Spectrum Conforms to Structure
Miscellaneous Assay (Epoxy Eq. wt (HCl-Dioxane Method)) 264 - 290
Specific Gravity (at 25 °C) 1,10 - 1,20
Viscosity (at 25 °C) 60 - 110 cps
Water (by Karl Fischer) ≤1,0%
Color Test ≤200 APHA
Refractive Index   n20/D 1,47
Storage Temperature 2 to 8 °C

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