(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®
Supplier: Merck Millipore Calbiochem
Ratings:
(No Reviews)
Total Ratings: 0
Avg. Ratings: 0.0 out of 5
361550-1
361550-10MG
361550-30MG
361550-1EA
144
GBP
361550-1
361550-10MG
361550-30MG
(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM).
Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells.
Formula:
C₁₆H₁₀BrN₃O₂ |
MDL Number:
MFCD08705318 CAS Number: 667463-62-9 |
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