Trifluoroacetic anhydride

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Synonyms: Trifluoracetic anhydride, TFAA

35619 35618
REST35619EA 0 GBP
REST35619 REST35618
Trifluoroacetic anhydride
Trifluoroacetic anhydride

Acylation derivatization reagent.


  • Most commonly used for electron capture detection
  • React with alcohols, amines, and phenols
  • Frequently used for drugs of abuse confirmation


Acylation reagents offer the same advantage available from silylation reagents: creating less polar, more volatile derivatives. In comparison to silylating reagents, the acylating reagents can more readily target highly polar multifunctional compounds, such as carbohydrates and amino acids. In addition, acylating reagents offer the distinct advantage of introducing electron-capturing groups, thus enhancing detectability during analysis.

Formula: C₄F₆O₃
MW: 210.03 g/mol
MDL Number: MFCD00000416
CAS Number: 407-25-0
UN: 3265
ADR: 8,I

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