Anti-TYMS Mouse Monoclonal Antibody (CF568) [clone: TS106 TMS715]

Supplier: Biotium
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BNC680716-500 BNC680716-100
BNC680716-500EA 533 GBP
BNC680716-500 BNC680716-100
Anti-TYMS Mouse Monoclonal Antibody (CF568) [clone: TS106 TMS715]
Antibodies
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. ExpressionMore Product Information
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