You Searched For: Sulpho-EMCS (N-(ε-maleimidocaproyloxy) sulphosuccinimide ester)

Catalog Number: (BC17)

Supplier: G-Biosciences

Description: N-(ε-Maleimidocaproyloxy) sulfo succinimide ester Heterobifunctional Cross Linker.

UOM: 1 * 50 mg

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Catalog Number: (PIER22307)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Sulfo-EMCS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).

UOM: 1 * 50 mg

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Catalog Number: (SIAL803235-50MG)

Supplier: Merck

Description: EMCS and its water-soluble analog Sulfo-EMCS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

UOM: 1 * 50 mg

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