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You Searched For: 1,9-Pyrazoloanthrone


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1,9-Pyrazoloanthrone ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

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1,9-Pyrazoloanthrone ≥99%

Supplier: Apollo Scientific
Description: Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 uM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. Proc. Natl. Acad. Sci. USA 98: 13681-13686 (2001).

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1,9-Pyrazoloanthrone 99%

Supplier: Thermo Fisher Scientific
Description: 1,9-Pyrazoloanthrone 99%

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