Pegylation reagent, MT(PEG)₄ methyl-PEG-thiol compound

Supplier: Thermo Fisher Scientific
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26132
PIER26132EA 374 GBP
PIER26132
Pegylation reagent, MT(PEG)₄ methyl-PEG-thiol compound
Protein Purification Protein Purification Reagents

Methyl-PEG4-thiol is a methyl- and sulfhydryl-terminated compound that contains a 4-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.


  • PEG groups are flexible, non-immunogenic and hydrophilic
  • Terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding
  • Terminal methyl group coats quantum dot and other surfaces to reduce nonspecific binding in assays


The use of MT(PEG)4 with CT(PEG)12 in surface modification can form a hydrophilic "lawn" of methyl ether-terminated PEGs with periodic exposed carboxylic acid-containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulpho-NHS.

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