Anti-ATM Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Supplier: Bioss
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BS-1370R-HRP
BOSSBS-1370R-HRPEA 828 GBP
BOSSBS-1370R-HRP
Anti-ATM Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))
Antibodies
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-More Product Information
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